Show simple item record

dc.contributor.authorLane, Ciaran
dc.date.accessioned2016-01-19T18:49:11Z
dc.date.available2016-01-19T18:49:11Z
dc.identifier.urihttp://hdl.handle.net/10222/65331
dc.description.abstractNon-Catalytic region of tyrosine Kinase (NCK) adaptor proteins connect cell surface receptors to the actin cytoskeleton. In the central nervous system loss of NCK proteins leads to a hopping like phenotype¬. We were interested in examining the expression of these proteins in the spinal cord development and better defining their role in global processes of axon guidance. Further, since in vitro studies have shown that NCK associates with the netrin receptor Deleted in Colorectal Cancer (DCC) we set out to determine is loss of NCK affected DCC sensitive pathways in vivo. Thus, the purpose of our study was to better define the in vivo role for NCK in the developing nervous system. Here we found NCK-deficiency causes growth cone defects and increased axon length. Together, these studies reveal the importance of NCK proteins in neuronal development, and show that NCK is required for normal guidance of DCC positive axons.en_US
dc.language.isoenen_US
dc.subjectMolecular Biologyen_US
dc.subjectSpinal Corden_US
dc.subjectDevelopmenten_US
dc.titleThe Role of NCK in DCC-Sensitive Spinal Cord Circuitsen_US
dc.typeThesis
dc.date.defence2013-08-16
dc.contributor.departmentDepartment of Pharmacologyen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinerYing Zhangen_US
dc.contributor.graduate-coordinatorJana Sawynoken_US
dc.contributor.thesis-readerJana Sawynoken_US
dc.contributor.thesis-readerJason McDougallen_US
dc.contributor.thesis-supervisorJames Fawcetten_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
 Find Full text

Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record