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dc.contributor.authorWijesundara, Niluni
dc.date.accessioned2015-12-18T19:53:07Z
dc.date.available2015-12-18T19:53:07Z
dc.identifier.urihttp://hdl.handle.net/10222/64730
dc.description.abstractStreptococcal pharyngitis is a significant health issue worldwide. Antibiotics and non-steroidal anti-inflammatory drugs are often prescribed as treatments. However, discovery of specific phytochemicals as novel antimicrobials agents or analgesic natural health product could help in overcoming the therapeutic challenges. In this study, 32 phytochemical extracts were investigated for anti-streptococcal and anti-inflammatory activity in vitro. Ethanol extract of licorice roots, sage leaves and echinacea flowers and essential oils of sage leaves and oregano flowering shoots showed significant inhibition of growth and biofilm formation of Streptococcus pyogenes. Furthermore, aqueous extracts of ginger rhizome, clove buds, echinacea flowers, thyme flowering shoots and ethanolic extracts of danshen roots showed greater in vitro anti-inflammatory activity on human tonsil epithelial cells. Therefore, considering both antimicrobial and analgesic abilities, extracts of oregano, sage, licorice, echinacea and thyme may have the potential to be used as natural health products, in the management of streptococcal pharyngitis.en_US
dc.language.isoenen_US
dc.subjectAnti-streptococcalen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAnti-biofilmen_US
dc.subjectPhytochemicalsen_US
dc.subjectStreptococcal pharyngitisen_US
dc.titleExploration of Phytochemical-Rich Extracts of Selected Canadian Plants Against Streptococcal Pharyngitisen_US
dc.typeThesis
dc.date.defence2015-12-07
dc.contributor.departmentFaculty of Agricultureen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorDr. Dian Pattersonen_US
dc.contributor.thesis-readerDr. Ross Davidsonen_US
dc.contributor.thesis-readerDr. John Rohdeen_US
dc.contributor.thesis-readerDr. Nancy Pittsen_US
dc.contributor.thesis-supervisorDr. Vasantha Rupasingheen_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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