Statistical Methods for the Analysis of Case Series Data
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This paper compares the three methods -conditional Poisson method, unconditional Poisson method and self-controlled case series (SCCS) method, based on the retrospective cohort study with full cohort and case series sampling designs, with particular emphasis on their assumptions, power, MSE, relative efficiency, and handling of confounding. The performance of the three methods is contrasted in a study investigating the causality between vaccination and rare adverse events seizures. And we extend these methods to random effect model.