Show simple item record

dc.contributor.authorMcCluskey, Greg
dc.date.accessioned2013-10-28T16:19:07Z
dc.date.available2013-10-28T16:19:07Z
dc.date.issued2013-10-28
dc.identifier.urihttp://hdl.handle.net/10222/37800
dc.description.abstractBreast cancer is characterized in part by chronic inflammation and tissue remodelling in the mammary gland. Adipocyte enhancer binding protein 1 (AEBP1), a pro-inflammatory protein, is up-regulated in breast cancer and enhances cytokine secretion in the mammary tumour microenvironment. AEBP1 over-expression in cultured macrophages resulted in increased enzymatic activity of MMP-9, a matrix metalloproteinase implicated in processing cytokines and stimulating tumour cell growth and mobility. MMP-9 activates the cytokine tumour necrosis factor-alpha (TNF?), and is required for the transformation of epithelial cells by the cytokine interleukin 6 (IL6). Treatment of epithelial cells with TNF? and IL6, both of which promote tumourigenesis, induced AEBP1 expression. Chromatin immunoprecipitation results suggested AEBP1 induction is directly mediated by pro-inflammatory transcription factors NF-?B and STAT3, downstream effectors of TNF? and IL6, respectively. AEBP1 induction may enhance inflammation, thereby contributing to cell proliferation and survival.en_US
dc.language.isoenen_US
dc.subjectAEBP1 cancer tumourigenesis mmp il6 tnf macrophage mammary gland cytokine signallingen_US
dc.titleAEBP1 ALTERS MATRIX SIGNALLING AND IS RESPONSIVE TO INFLAMMATION IN THE MAMMARY GLANDen_US
dc.date.defence2012-08-17
dc.contributor.departmentDepartment of Biochemistry & Molecular Biologyen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinerN/Aen_US
dc.contributor.graduate-coordinatorDr. Richard Singeren_US
dc.contributor.thesis-readerDr. Melanie Dobsonen_US
dc.contributor.thesis-readerDr. Graham Dellaireen_US
dc.contributor.thesis-readerDr. Neale Ridgwayen_US
dc.contributor.thesis-supervisorDr. Hyo-Sung Roen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
 Find Full text

Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record