Biochemistry and Molecular Biology Faculty Research, Publications and Presentations

The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction

Platt, F. M., B. Boland, and A. C. van der Spoel. 2012. "The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction." The Journal of cell biology 199(5): 723-734. doi:10.1083/jcb.201208152

Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in lysosomal enzymes, but also in some non-enzymatic ...

The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study

Bone, Wilhelm, Charlotte M. Walden, Martin Fritsch, Ulrike Voigtmann, et al. 2007. "The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study." Reproductive Biology and Endocrinology 5: 1-1. doi:10.1186/1477-7827-5-1

No abstract available.

FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation

Stevens, J. R., A. F. O'Donnell, T. E. Perry, J. J. R. Benjamin, et al. 2011. "FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation." PLoS ONE 6(10).

Gene transcription is constrained by the nucleosomal nature of chromosomal DNA. This nucleosomal barrier is modulated by FACT, a conserved histone-binding heterodimer. FACT mediates transcription-linked nucleosome disassembly ...

Mutational analysis of the Prt1 protein subunit of yeast translation initiation factor 3

Evans, D. R. H., C. Rasmussen, P. J. Hanic-Joyce, G. C. Johnston, et al. 1995. "Mutational analysis of the Prt1 protein subunit of yeast translation initiation factor 3." Molecular and cellular biology 15(8): 4525-4535.

The Saccharomyces cerevisiae PRT1 gene product Prt1p is a component of translation initiation factor eIF-3, and mutations in PRT1 inhibit translation initiation. We have investigated structural and functional aspects of ...

Autophagy Enhances Bacterial Clearance during P. aeruginosa Lung Infection

Junkins, Robert D., Ann Shen, Kirill Rosen, Craig McCormick, et al. 2013. "Autophagy Enhances Bacterial Clearance during P. aeruginosa Lung Infection." Plos One 8(8): 72263-e72263. doi:10.1371/journal.pone.0072263

No abstract available.

Molecular phylogeny of diplomonads and enteromonads based on SSU rRNA, alpha-tubulin and HSP90 genes: Implications for the evolutionary history of the double karyomastigont of diplomonads

Kolisko, Martin, Ivan Cepicka, Vladimir Hampl, Jessica Leigh, et al. 2008. "Molecular phylogeny of diplomonads and enteromonads based on SSU rRNA, alpha-tubulin and HSP90 genes: Implications for the evolutionary history of the double karyomastigont of diplomonads." Bmc Evolutionary Biology 8: 205-205.

No abstract available.

The ArfGAP Glo3 is required for the generation of COPI vesicles

Lewis, SM, PP Poon, RA Singer, GC Johnston, et al. 2004. "The ArfGAP Glo3 is required for the generation of COPI vesicles." Molecular biology of the cell 15(9): 4064-4072.

No abstract available.

Multiple lateral transfers of dissimilatory sulfite reductase genes between major lineages of sulfate-reducing prokaryotes

Klein, M., M. Friedrich, AJ Roger, P. Hugenholtz, et al. 2001. "Multiple lateral transfers of dissimilatory sulfite reductase genes between major lineages of sulfate-reducing prokaryotes." Journal of Bacteriology 183(20): 6028-6035.

No abstract available.

Gene-content evolution in discobid mitochondria deduced from the phylogenetic position and complete mitochondrial genome of Tsukubamonas globosa

Kamikawa, R., M. Kolisko, Y. Nishimura, A. Yabuki, et al. 2014. "Gene-content evolution in discobid mitochondria deduced from the phylogenetic position and complete mitochondrial genome of Tsukubamonas globosa." Genome biology and evolution.

The unicellular eukaryotic assemblage Discoba (Excavata) comprises four lineages: the Heterolobosea, Euglenozoa, Jakobida and Tsukubamonadida. Discoba has been considered as a key assemblage for understanding the early ...

The Saccharomyces-Cerevisiae Myo2 Gene Encodes an Essential Myosin for Vectorial Transport of Vesicles

JOHNSTON, GC, JA PRENDERGAST, and RA SINGER. 1991. "The Saccharomyces-Cerevisiae Myo2 Gene Encodes an Essential Myosin for Vectorial Transport of Vesicles." Journal of Cell Biology 113(3): 539-551.

No abstract available.

Parallel re-modeling of EF-1 alpha function: divergent EF-1 alpha genes co-occur with EFL genes in diverse distantly related eukaryotes

Kamikawa, Ryoma, Matthew W. Brown, Yuki Nishimura, Yoshihiko Sako, et al. 2013. "Parallel re-modeling of EF-1 alpha function: divergent EF-1 alpha genes co-occur with EFL genes in diverse distantly related eukaryotes." Bmc Evolutionary Biology 13: 131-131.

No abstract available.

Ornithine Decarboxylase Activity and Cell-Cycle Regulation in Saccharomyces-Cerevisiae

KAY, DG, RA SINGER, and GC JOHNSTON. 1980. "Ornithine Decarboxylase Activity and Cell-Cycle Regulation in Saccharomyces-Cerevisiae." Journal of Bacteriology 141(3): 1041-1046.

No abstract available.

Growth and Cell-Division during Nitrogen Starvation of Yeast Saccharomyces-Cerevisiae

JOHNSTON, GC, RA SINGER, and ES MCFARLANE. 1977. "Growth and Cell-Division during Nitrogen Starvation of Yeast Saccharomyces-Cerevisiae." Journal of Bacteriology 132(2): 723-730.

No abstract available.

Genetic Evidence for a Mitochondriate Ancestry in the 'Amitochondriate' Flagellate Trimastix pyriformis

Hampl, Vladimir, Jeffrey D. Silberman, Alexandra Stechmann, Sara Diaz-Trivino, et al. 2008. "Genetic Evidence for a Mitochondriate Ancestry in the 'Amitochondriate' Flagellate Trimastix pyriformis." Plos One 3(1): 1383-e1383.

No abstract available.

Assessing functional divergence in EF-1 alpha and its paralogs in eukaryotes and archaebacteria

Inagaki, Y., C. Blouin, E. Susko, and AJ Roger. 2003. "Assessing functional divergence in EF-1 alpha and its paralogs in eukaryotes and archaebacteria." Nucleic acids research 31(14): 4227-4237.

No abstract available.

"Sleeping beauty": Quiescence in Saccharomyces cerevisiae

Gray, JV, GA Petsko, GC Johnston, D. Ringe, et al. 2004. ""Sleeping beauty": Quiescence in Saccharomyces cerevisiae." Microbiology and Molecular Biology Reviews 68(2): 187-+.

No abstract available.

Invasion and Persistence of a Selfish Gene in the Cnidaria

Goddard, Matthew R., Jessica Leigh, Andrew J. Roger, and Andrew J. Pemberton. 2006. "Invasion and Persistence of a Selfish Gene in the Cnidaria." Plos One 1(1): 3-e3.

No abstract available.

Convergence and constraint in eukaryotic release factor 1 (eRF1) domain 1: the evolution of stop codon specificity

Inagaki, Y., C. Blouin, WF Doolittle, and AJ Roger. 2002. "Convergence and constraint in eukaryotic release factor 1 (eRF1) domain 1: the evolution of stop codon specificity." Nucleic acids research 30(2): 532-544.

No abstract available.

Mutational Analysis of Dark Endogenous Metabolism in Blue-Green Bacterium Anacystis-Nidulans

, , and RA SINGER. 1974. "Mutational Analysis of Dark Endogenous Metabolism in Blue-Green Bacterium Anacystis-Nidulans." Journal of Bacteriology 119(3): 677-683.

No abstract available.

Evolutionary analyses of the small subunit of glutamate synthase: Gene order conservation, gene fusions, and prokaryote-to-eukaryote lateral gene transfers

Andersson, JO, and AJ Roger. 2002. "Evolutionary analyses of the small subunit of glutamate synthase: Gene order conservation, gene fusions, and prokaryote-to-eukaryote lateral gene transfers." Eukaryotic Cell 1(2): 304-310.

No abstract available.