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The clinical meaningfulness of ADAS-Cog changes in Alzheimer’s disease patients treated with donepezil in an open-label trial
(BMC Springer Nature, 2007-08-30)
Background: In 6-month anti-dementia drug trials, a 4-point change in the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) is held to be clinically important. We examined how this change compared with ...
Lueurs et leurres de la santé globale À propos de MenAfriVac®, un vaccin « africain » contre la méningite
(Open Edition Journals, 2017-12)
In biomedical narratives, the Meningitis Vaccine Project (MVP) enabled the technology transfer for the development and implementation of MenAfriVac® vaccine at an affordable price for African countries. The presentation ...
Oncogenic ras-induced downregulation of a pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells
(Journal of Biological Chemistry, 2011-11-11)
Resistance of carcinoma cells to anoikis, apoptosis that is normally induced by loss of cell-to-extracellular matrix (ECM) adhesion, is thought to be essential for the ability of these cells to form primary tumors, invade ...
Prepared for the “unexpected”? Lessons from the 2014-16 Ebola epidemic in West Africa on integrating emergent theory designs into outbreak response.
(BMJ Publishing Group, 2018-06)
Summary Box
1. Even seemingly straightforward interventions, such as vaccine delivery, require real-time awareness of emergent on-the-ground local (‘field’) realities.
2. Outbreak response requires thoughtful engagement ...
Risks of nutrigenomics and nutrigenetics? What the scientists say.
(BMC Springer Nature, 2013-11-29)
Nutrigenomics and nutrigenetics (hereafter NGx) have stimulated expectations for beneficial applications in public health and individuals. Yet, the potential achievability of such promise is not without socioethical ...
Global challenges of implementing human papillomavirus vaccines
(BMC Springer Nature, 2011)
Human Papillomavirus vaccines are widely hailed as a sweeping pharmaceutical innovation for the universal benefit of all women. The implementation of the vaccines, however, is far from universal or equitable. Socio- ...
Estimating sensitivity of laboratory testing for influenza in Canada through modelling
(Public Library of Science, 2009)
Do health care providers trust product monograph information regarding use of vaccines in pregnancy? A qualitative study
(Health Canada, 2018-06-07)
Background: In uenza immunization is recommended in pregnancy to prevent severe infections in pregnant women and newborns, yet vaccine uptake remains low. Studies suggest that cautionary language in vaccine product monographs ...
Teaching Heart Auscultation to Health Professionals: Methods for Improving the Practice of an Ancient but Critical Skill
(Canadian Pediatric Cardiology Association, 2015)