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The clinical meaningfulness of ADAS-Cog changes in Alzheimer’s disease patients treated with donepezil in an open-label trial
(BMC Springer Nature, 2007-08-30)
Background: In 6-month anti-dementia drug trials, a 4-point change in the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) is held to be clinically important. We examined how this change compared with ...
Lueurs et leurres de la santé globale À propos de MenAfriVac®, un vaccin « africain » contre la méningite
(Open Edition Journals, 2017-12)
In biomedical narratives, the Meningitis Vaccine Project (MVP) enabled the technology transfer for the development and implementation of MenAfriVac® vaccine at an affordable price for African countries. The presentation ...
Prepared for the “unexpected”? Lessons from the 2014-16 Ebola epidemic in West Africa on integrating emergent theory designs into outbreak response.
(BMJ Publishing Group, 2018-06)
Summary Box
1. Even seemingly straightforward interventions, such as vaccine delivery, require real-time awareness of emergent on-the-ground local (‘field’) realities.
2. Outbreak response requires thoughtful engagement ...
Risks of nutrigenomics and nutrigenetics? What the scientists say.
(BMC Springer Nature, 2013-11-29)
Nutrigenomics and nutrigenetics (hereafter NGx) have stimulated expectations for beneficial applications in public health and individuals. Yet, the potential achievability of such promise is not without socioethical ...
Global challenges of implementing human papillomavirus vaccines
(BMC Springer Nature, 2011)
Human Papillomavirus vaccines are widely hailed as a sweeping pharmaceutical innovation for the universal benefit of all women. The implementation of the vaccines, however, is far from universal or equitable. Socio- ...
Do health care providers trust product monograph information regarding use of vaccines in pregnancy? A qualitative study
(Health Canada, 2018-06-07)
Background: In uenza immunization is recommended in pregnancy to prevent severe infections in pregnant women and newborns, yet vaccine uptake remains low. Studies suggest that cautionary language in vaccine product monographs ...
Assessment of factors associated with complete immunization coverage in children ages 12-23 months: A cross sectional study in Nouna district, Burkina Faso
(BMC Springer Nature, 2009-10-14)
Background: The Expanded Program on Immunization (EPI) is still in need of improvement. In Burkina Faso in 2003, for example, the Nouna health district had an immunization coverage rate of 31.5%, compared to the national ...
Challenges to immunization: the experience of homeless youth
(BMC Springer Nature, 2012)
Background: Homelessness is a critical social issue, both a product of, and contributing to, poor mental and physical health. Over 150,000 young Canadians live on the streets. Homeless youth experience a high incidence of ...
Frailty, fitness and late-life mortality in relation to chronological and biological age
(BMC Springer Nature, 2002-02-27)
Background: People age at remarkably different rates, but how to estimate trajectories of
senescence is controversial.
Methods: In a secondary analysis of a representative cohort of Canadians aged 65 and over (n = 2914) ...
Substitute Decision Making About Research: Identifying the Legally Authorized Representative in Four Canadian Provinces
(Faculty of Law, McGill University, 2012)
Canada's aging population presents new incentives for research on Alzheimer's and other forms of dementia. But the public interest in advancing knowledge about these diseases must be partnered with a concern for exploitation, ...