Browsing Faculty of Medicine by Author "176fadb1-c3ef-4b2f-8fba-958854763780"
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The clinical meaningfulness of ADAS-Cog changes in Alzheimer’s disease patients treated with donepezil in an open-label trial
Rockwood, Kenneth; Fay, Sherri; Gorman, Mary; Carver, Daniel; Graham, Janice (BMC Springer Nature, 2007-08-30)Background: In 6-month anti-dementia drug trials, a 4-point change in the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) is held to be clinically important. We examined how this change compared with ... -
Frailty, fitness and late-life mortality in relation to chronological and biological age
Mitnitski, Arnold; Graham, Janice; Mogilner, Alexander; Rockwood, Kenneth (BMC Springer Nature, 2002-02-27)Background: People age at remarkably different rates, but how to estimate trajectories of senescence is controversial. Methods: In a secondary analysis of a representative cohort of Canadians aged 65 and over (n = 2914) ...