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Now showing items 91-100 of 2079
Cellular and Subcellular Mechanisms of Ventricular Mechano-Arrhythmogenicity
(2021-07-15)
The heart is an electro-mechanical pump with feedback mechanisms for responding to acute changes in its mechanical environment. This requires cellular and subcellular elements of cardiac mechano-sensitivity, including ...
VARIABILITY OF CIRCULATION AND SEA ICE OVER THE EASTERN CANADIAN SHELF AND IN THE ADJACENT NORTHERN NORTH ATLANTIC OCEAN
(2021-07-14)
A significant gap remains in our understanding regarding the temporal-spatial variability of hydrodynamics over the eastern Canadian shelf (ECS) and in the adjacent northern North Atlantic Ocean (nNA). This thesis is a ...
Coastline as Commons: Using Spatial Devices to Link Littoral Temporalities
(2021-08-12)
This thesis argues that architectural interventions can extend the water commons to the fluctuating littoral zone of Kjipuktuk/Halifax Harbour. The present composition of the Harbour as a working waterway favours a colonial ...
PALEOLIMNOLOGY AS A QUANTITATIVE INDICATOR OF ECOSYSTEM VULNERABILITY
(2021-08-20)
External stressors to freshwater systems present challenges for management. Stress can exacerbate ecosystem vulnerability, which is a result of numerous components, making quantifying vulnerability logistically difficult. ...
Numerical study of sea ice dynamics and wave-ice interactions in the marginal ice zone
(2021-04-30)
The Marginal Ice Zone (MIZ) is a highly dynamic region between the open ocean and the inner ice pack. The ice over this region is subjected to waves, introducing new forces but also changing the ice from a cohesive material ...
Combination Drug Discovery in the Treatment of Multidrug-resistant Preclinical Models of Breast Cancer
(2021-11-15)
Therapeutic resistance is the culprit behind most cancer-related relapse and death, accounting for over 90% chemotherapeutic intervention failures. To combat the genetic and phenotypical abnormalities associated with ...
Voluntary Aerobic Exercise Attenuates Frailty in a Sex-Specific Manner in Older Male and Female C67Bl/6 Mice
(2021-08-27)
Aerobic exercise is thought to improve overall health and reduce frailty, but whether this is beneficial in both sexes is unclear. We introduced voluntary wheel running to older (~22 months) male and female mice to see if ...
Using Integrated Environmental Change Study Methods to Understand Factors Influencing Harmful Algae Blooms in a Rural Headwater Lake
(2021-08-13)
Eutrophication and algae production are an important lake management issue in rural Nova Scotia. In the past decade, there have been increasing instances of harmful algae bloom (HAB) events in previously unaffected surface ...
Studying Behavior of Cultured Atlantic Salmon (Salmo salar) using 3D Acoustic Telemetry in Nova Scotia, Canada
(2021-09-01)
Climate change is altering ocean environments worldwide, requiring a better understanding
of how these shifting will affect fish welfare in aquaculture farms. Storms have increased
in strength and frequency, potentially ...
Novel Approaches to Marker Gene Representation Learning Using Trained Tokenizers and Jointly Trained Transformer Models
(2021-08-19)
Next-generation DNA sequencing technologies have made marker-gene DNA sequence data widely available. Analysis of microbiome data has many challenges, including sparsity, high cardinality, and intra-study dependencies ...