Browsing Faculty of Graduate Studies Online Theses by Subject "Virology"
Now showing items 1-6 of 6
-
FUNCTIONAL INTERPLAY OF INFLUENZA A VIRUS NS1 AND PA-X PROTEINS MEDIATES HOST SHUTOFF
(2022-11-18)Host shutoff is a mechanism to inhibit gene expression and limit the innate immune response. IAV produces two host shutoff proteins: PA-X and NS1. PA-X is an endonuclease that targets and cleaves host mRNAs. NS1 limits ... -
INFLUENZA A VIRUS INFECTION AND UFMYLATION
(2024-06-23)This thesis investigates the interplay between UFMylation, a post-translational modification involving the conjugation of the ubiquitin-like protein Ubiquitin-fold modifier 1 (UFM1) to target proteins, and the replication ... -
KAPOSIN B-MEDIATED MECHANORESPONSIVE SIGNALLING CONTROLS PROCESSING BODY DISASSEMBLY
(2020-09-11)Kaposin B (KapB) is a viral protein that induces the formation of actin stress fibres (SFs) and promotes stabilization of inflammatory and angiogenic mRNAs by disassembling processing bodies (PBs). PBs are ribonucleoprotein ... -
Mechanistic Contributions of the p10 FAST Protein Ectodomains to Membrane Fusion and Syncytiogenesis
(2013-12-16)The homologous p10 fusion-associated small transmembrane (FAST) proteins of the fusogenic avian (ARV) and Nelson Bay (NBV) reoviruses are the smallest known proteins capable of mediating syncytiogenesis. Their extremely ... -
Role of Membrane Curvature and Exosome Secretion during FAST-Mediated Cell-Cell Fusion
(2016-12-05)The fusogenic reoviruses are a unique group of viruses that encode Fusion-Associated Small Transmembrane (FAST) proteins, a family of non-structural membrane proteins that induce cell-cell membrane fusion in infected cells. ... -
Small Cell-Cell Fusogens Activate a PI3K-mTORC2-Akt Signalling Axis and Macropinocytosis for Efficient Cell Fusion
(2023-08-18)Cell-cell fusion is mediated by distinct types of protein fusogens. Class I, II and III enveloped virus fusogens facilitate fusion through interaction with receptors on an apposing membrane that trigger conformational ...