Browsing Faculty of Graduate Studies Online Theses by Subject "Multiple sclerosis"
Now showing items 1-5 of 5
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Angiogenesis as a pathologic mechanism and novel therapeutic target in an animal model of multiple sclerosis
(2013-03-22)Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system. We hypothesize that angiogenesis results in new vessels which serve as a conduit for immune cell recruitment in MS, and contribute ... -
CHARACTERIZATION OF GAIT DEFICITS IN A MOUSE MODEL OF MULTIPLE SCLEROSIS
(2017-09-15)Neurological deficits in mice subjected to experimental autoimmune encephalomyelitis (EAE) are typically scored using a clinical scale (CS) with 5-10 levels of ascending paralysis and impaired gait. However, CS scoring is ... -
CONTRIBUTION OF THE VOLTAGE-GATED SODIUM CHANNEL NAV1.6 AND TOLL LIKE RECEPTOR 2 IN THE PATHOPHYSIOLOGY OF EAE
(2021-05-05)Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating, and neurodegenerative disorder of the central nervous system (CNS) with the highest worldwide prevalence existing in Canada and affecting over 3000 Nova ... -
PIOGLITAZONE IS SUPERIOR TO QUETIAPINE, CLOZAPINE AND TAMOXIFEN AT ALLEVIATING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2018-07-03)Recent evidence suggests that clozapine, quetiapine, tamoxifen and pioglitazone may improve functional recovery in multiple sclerosis (MS). We have compared the effectiveness of oral administration of these drugs, beginning ... -
REMYELINATION IS ACCELERATED BY EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS: A NOVEL MODEL FOR THE ELUCIDATION OF IMMUNE-MEDIATED BRAIN REPAIR
(2019-11-28)Introduction: Experimental autoimmune encephalomyelitis (EAE) and lysophosphatidylcholine (LPC)-induced demyelination are common rodent models of multiple sclerosis (MS). Clozapine and pioglitazone, two drugs used in the ...