Browsing Faculty of Graduate Studies Online Theses by Subject "Multiple Sclerosis"
Now showing items 1-7 of 7
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Comorbidity and persistence of disease-modifying therapy use for relapsing remitting multiple sclerosis
(2020-10-29)Comorbidity may impact use of disease-modifying therapies (DMTs) among individuals with relapsing remitting multiple sclerosis (RRMS). Our objectives were to characterize the relationship between comorbidity and (1) ... -
THE EFFECTS OF THE PROTEOGLYCAN ANTAGONIST SURFEN ON ANIMAL MODELS OF DEMYELINATION WITH COMPARISON TO IN VITRO T CELL AND MACROPHAGE RESPONSES
(2018-05-23)Multiple sclerosis (MS) is a debilitating neurodegenerative disorder that currently affects over 3000 Nova Scotians, and is characterized by the autoimmune-mediated destruction of myelin and axons in the central nervous ... -
EXAMINING SINGLE-SUBJECT RELIABILITY OF FUNCTIONAL MAGNETIC RESONANCE IMAGING IN ESTABLISHED MULTIPLE SCLEROSIS
(2014-12-10)Multiple sclerosis (MS) is the most common chronic inflammatory and neurodegenerative disease affecting the central nervous system. Conventional magnetic resonance imaging (MRI) has an invaluable role in the early diagnosis ... -
Health Promotion Experiences and Ideas for Health Promotion Improvements: An Interpretative Phenomenological Study of Nova Scotian Women with Multiple Sclerosis Through a Feminist, Disability Rights Lens
(2014-08-26)Most research in health promotion uses quantitative methodology to better understand the health promotion experiences of people with disabilities. This qualitative thesis study used Interpretative Phenomenologist Analysis ... -
INTRA-INDIVIDUAL VARIABILITY IS AN IMPORTANT CHARACTERISTIC OF COGNITIVE FUNCTIONING IN PERSONS WITH MULTIPLE SCLEROSIS
(2013-08-20)Cognitive deficits are highly prevalent in multiple sclerosis (MS) and have a negative impact on daily life. Impairments in information processing speed are among the most commonly reported deficits in MS and are generally ... -
MODULATION OF IMMUNE FUNCTION AND PROMOTION OF RESTORATIVE GENE EXPRESSION BY AF4 IN A MOUSE MODEL OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2014-02-25)The anti-inflammatory and restorative effects of the flavonoid-enriched fraction AF4 were examined in a mouse model of experimental autoimmune encephalomyelitis (EAE). Relative to EAE mice that received vehicle (water, 10 ... -
NEURONAL MITOCHONDRIAL CALCIUM UNIPORTER DEFICIENCY EXACERBATES AXONAL INJURY AND SUPPRESSES REMYELINATION IN MICE SUBJECTED TO EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2020-08-12)High-capacity mitochondrial calcium (Ca2+) uptake by the mitochondrial Ca2+ uniporter (MCU) is strategically positioned to support the survival and remyelination of axons in multiple sclerosis (MS) by undocking mitochondria, ...