Browsing Faculty of Graduate Studies Online Theses by Subject "Mitochondria"
Now showing items 1-8 of 8
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AUTOTAXIN IS NUTRITIONALLY REGULATED AND ALTERS MITOCHONDRIAL FUNCTION IN OBESITY-INDUCED INSULIN RESISTANCE
(2019-08-28)The skeletal muscle is a major site of insulin stimulated glucose disposal. Skeletal muscle insulin sensitivity can be influenced by multiple circulating nutritional, hormonal, neuronal and bioactive factors, including ... -
EXPLORING THE ROLE OF MITOCHONDRIAL CHOLESTEROL IN NIEMANN-PICK TYPE C DISEASE
(2016-01-19)Niemann-Pick type C (NPC) disease is an autosomal recessive neurodegenerative disorder caused by mutations in Npc1 or Npc2 gene. Npc1 and Npc2 encode a late-endosomal transmembrane and lumenal cholesterol-binding domain ... -
Glycosphingolipid Metabolism and the Glycosphingolipid-Metabolizing Enzyme Beta-Glucosidase 2: Biochemical and Cell Biological Studies
(2021-01-07)Glycosphingolipids (GSLs) are constituents of eukaryotic cell membranes and consist of a lipid (ceramide) linked to one or more sugar residues. GSLs occur in many structurally distinct forms, varying in both their lipid ... -
Inhibition of the mitochondrial calcium uniporter complex (MCUcx) as a neuroprotective strategy for ischemic stroke
(2023-08-03)Ischemic stroke, typically caused by a clot that blocks a major cerebral artery, is a leading cause of death and disability. Despite intense effort, a viable protective strategy has yet to emerge. Mitochondrial dysfunction, ... -
MITOCHONDRIAL DAMAGE-ASSOCIATED MOLECULAR PATTERNS IMPACT LYMPHOCYTE FUNCTION AND CORRELATE WITH ORGAN HEALTH DURING NORMOTHERMIC MACHINE PERFUSION
(2024-02-06)Damage-associated molecular pattern (DAMP) molecules from mitochondria (mitoDAMPs) are released following tissue injury. Innate immune cells promote inflammation in response to mitoDAMPs, yet how this is controlled and ... -
NEUROPROTECTION AFTER TRAUMATIC SPINAL CORD INJURY THROUGH MITOCHONDRIAL CALCIUM UNIPORTER INHIBITION
(2022-07-28)A common final pathway of secondary spinal cord injury (sSCI) is glutamate excitotoxicity, manifested by calcium (Ca2+) overloading of the neuron. Mitochondria are damaged by excessive intake of cytoplasmic Ca2+ through ... -
THE ROLE OF LIPID PHOSPHATE PHOSPHATASE 3 IN CARDIAC ENERGY METABOLISM
(2023-07-31)Lysophosphatidic acid (LPA) is a bioactive lipid that is generated by autotaxin (ATX) in circulation and is implicated in obesity induced cardiomyopathy. LPA signaling is terminated by lipid phosphate phosphatase 3 (LPP3) ... -
THE ROLE OF NPC2 IN CHOLESTEROL TRANSPORT AND THE ENDOCYTIC SYSTEM IN NEUROBLASTOMA CELLS
(2022-04-28)Niemann-Pick type C (NPC) disease is an autosomal recessive, neurodegenerative disorder caused by mutations in either Niemann-Pick Type C1 (NPC1) or NPC2. NPC disease is a lysosomal lipid-storage disease characterized by ...