Browsing Faculty of Graduate Studies Online Theses by Subject "Jadomycins"
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THE ANTICANCER ACTIVITY AND MECHANISMS OF ACTION OF JADOMYCINS IN MULTIDRUG RESISTANT HUMAN BREAST CANCER CELLS
(2018-09-28)Breast cancer is the most common cancer in women, and approximately one third of all breast cancers will ultimately metastasize. Metastatic breast cancer is classified as an incurable disease. The development of multidrug ... -
THE EFFECTS OF SOLUTE CARRIER ORGANIC ANION TRANSPORTERS ON JADOMYCIN PHARMACOLOGY IN BREAST CANCER
(2018-08-29)Breast cancer is the most commonly diagnosed cancer in women, and often becomes multidrug-resistant (MDR). Jadomycins are experimental chemotherapeutics that maintain cytotoxicity in MDR breast cancer cells and investigating ... -
Natural Product Biosynthesis by Streptomyces venezuelae: Genetic Variants for Drug Discovery
(2017-12-05)Natural product biosynthesis in Streptomyces venezuelae ISP5230 was investigated in three ways. First, through precursor-directed jadomycin biosynthesis using non-proteinogenic amino acids (4-(aminomethyl)benzoic acid, ...