Browsing Faculty of Graduate Studies Online Theses by Subject "Hypoxia"
Now showing items 1-5 of 5
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ADENOSINE AS AN ENVIRONMENTAL STRESSOR AFFECTING HSP27 AND CXCR4 IN EPITHELIAL CELLS
(2013-03-20)Solid tumours are a hostile tissue environment in which the cells are exposed to many stresses including hypoxia. One consequence of hypoxic conditions is an increase in extracellular levels of the purine nucleoside ... -
ASSESSING TRANSCRIPTOMIC AND PHYSIOLOGICAL RESPONSES OF ENVIRONMENTAL STRESS IN MUSSELS (MYTILUS EDULIS) FROM TWO SITES AND SIZES TO DISCOVER MARKERS CAPABLE OF MONITORING MUSSEL HEALTH
(2022-08-15)The Prince Edward Island blue mussel (Mytilus edulis) aquaculture industry is being challenged by climate change induced environmental stressors, that is impacting mussel health and survival. Physiological responses of ... -
IMPROVED PREDICTION OF THE EFFECTS OF ANTHROPOGENIC STRESSORS IN THE GULF OF MEXICO THROUGH REGIONAL-SCALE NUMERICAL MODELING AND DATA ASSIMILATION
(2018-12-05)The Gulf of Mexico (GOM) is of great ecological and socio-economic importance; however, its ecosystems are increasingly stressed by anthropogenic pressures. Two of the most serious are excessive nutrient inputs from land ... -
RALOXIFENE SENSITIZES GLIOBLASTOMA CELLS TO HYPOXIA -INDUCED DEATH THROUGH INHIBITION OF STRESS GRANULE DISSOLUTION
(2021-01-07)Glioblastoma multiforme (GBM) is the most common primary malignant brain tumour and carries a uniformly poor prognosis. Despite aggressive therapy, median survival is only 14 months. Death typically results from treatment ... -
THE ROLE OF HEME REGULATORY ENZYMES IN MYOCYTES UNDER STRESS
(2016-09-06)The heme metabolism pathway remains a novel therapeutic target for heart failure treatment. However, how heme is regulated in the failing heart remains to be understood. To investigate the molecular mechanisms underlying ...