Browsing Faculty of Graduate Studies Online Theses by Subject "Frailty"
Now showing items 1-18 of 18
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THE ASSESSMENT OF FRAILTY IN COMMUNITY-DWELLING OLDER ADULTS: A FEASIBILITY AND VALIDATION STUDY
(2015-04-28)The assessment of frailty is challenging in the presence of diverging views on its clinical measurement. Frailty is a state of vulnerability, multidimensional, and dynamic. Frail older adults have a diminished physiological ... -
THE ASSOCIATION OF FRAILTY AND LONG-TERM ADVERSE OUTCOMES IN PEOPLE WHO ATTEND CARDIAC REHABILITATION
(2022-08-25)Background: Cardiac rehabilitation programs are the gold standard for supporting patients to recover from cardiac events such as a heart attack. Patients who enrol in cardiac rehabilitation are often older and are burdened ... -
Comparing Virtual and Center Based Cardiac Rehabilitation on Changes in Frailty
(2022-08-25)Cardiac rehabilitation (CR) is the gold standard for the secondary prevention of cardiovascular disease (CVD). Frailty defines health in ageing and is associated with adverse health outcomes. Evidence suggests traditional ... -
Constructing and validating a frailty index as a novel health measure in systemic lupus erythematosus
(2019-11-28)For patients with systemic lupus erythematosus (SLE), clinical outcomes are highly variable and challenging to predict. Such differences in susceptibility to adverse health outcomes can be quantified using a frailty index ... -
Defining Biomarkers of Frailty in the Kidney: Implications for Endobiotic and Xenobiotic Metabolism in Mice
(2023-08-08)Frailty describes individuals with increased susceptibility to adverse health outcomes. The frailty index (FI) quantifies frailty by measuring deficit accumulation. This project aimed to characterize the molecular signature ... -
DISRUPTION OF SLEEP AND CIRCADIAN RHYTHM ORGANIZATION AS RISK FACTORS FOR DIAGNOSIS OF ALZHEIMER’S DISEASE
(2016-08-26)Individuals commonly report disrupted nighttime sleep and daytime sleepiness in the early, preclinical, stages of Alzheimer’s disease (AD), as well as other dementias. Furthermore, there is accumulating evidence of a ... -
DRUG USE AND AGE ALTERS THE DRUG METABOLISM POTENTIAL OF THE HUMAN GUT MICROBIOME
(2016-08-23)While drugs play an important role in human health, the interaction between the human microbiome and the metabolism of drugs remains relatively unknown. Studies have demonstrated the microbiome's capability to metabolize ... -
Effects of Low Testosterone on Frailty and a Selective Androgen Receptor Modulator on Frailty, Frailty Mechanisms, and Cardiac Structure and Function in Older Mice
(2022-09-01)Frailty is a state of increased risk to health issues and can arise in older age and during disease. Low circulating levels of testosterone, especially in older men, are thought to predispose toward a frail state due to ... -
An Evaluation of the Impact of Physician Education on Prescribing for Hypertension in a Nursing Home
(2014-12-09)Background: Nursing home residents are a frail population with multiple co-morbidities, and at risk for polypharmacy and its associated adverse events. Nevertheless, most clinical practice guidelines (CPGs) do not consider ... -
EXAMINING THE ASSOCIATION BETWEEN DOMAINS OF FRAILTY AND 6-MONTH CHANGES IN HEALTH-RELATED QUALITY OF LIFE, LIVING STATUS, AND TREATMENT DECISIONAL REGRET AMONG OLDER PATIENTS REFERRED FOR CARDIAC SURGERY
(2020-12-15)Background: Frailty status, which takes function into account, may be a better measure for older patients’ health status. Frailty is a risk factor for various adverse outcomes after cardiac surgery. Objectives: The ... -
Frailty and Occupational Therapy in the Emergency Department
(2020-12-07)This paper details a health records review of older adults referred to an occupational therapy (OT) program in the emergency department (ED), examining this population’s prevalence of frailty, and the impact of frailty on ... -
THE IMPACT OF AGE AND FRAILTY ON CARDIAC FUNCTION IN HEALTH AND DISEASE CONDITIONS IN NATURALLY AGEING MICE
(2019-11-28)Frail people with cardiovascular disease experience worse outcomes and higher mortality than non-frail patients, but the links between frailty and myocardial function are unclear. Frailty was quantified as deficit accumulation ... -
Integrating Frailty and Physical Resilience to Improve Risk Estimation in Aging Populations
(2024-04-11)Background: Physical resilience, broadly defined as the ability to resist or recover from health stressors, is a relatively new concept in the field of aging, yet, anticipated as a potentially game-changing idea. In ... -
Investigating the role of frailty in the expression of dementia
(2020-08-28)Background: Frailty is related to neuropathological features of Alzheimer’s disease (AD) as well as cognitive decline and dementia. Objectives: 1) determine whether frailty moderates the relationship between neuropathology ... -
LONGITUDINAL MULTI-OMIC ANALYSIS OF THE EFFECTS OF INACTIVITY AND EXERCISE ON THE HUMAN MICROBIOME UNDER CONDITIONS OF SIMULATED MICROGRAVITY
(2024-09-26)The Canadian Ageing and Inactivity Study was the first Canadian head-down tilt bedrest study carried out in older adults to evaluate parallels between the effects of microgravity and biological ageing. Host-associated ... -
The relationship between frailty and the development and progression of HIV-Associated Neurocognitive Disorder (HAND)
(2021-04-12)Background: The objective of this study was to determine the relationship between frailty and the development and progression of HIV-Associated Neurocognitive Disorder (HAND). Methods: This study used data from the ... -
THE RELATIONSHIP BETWEEN HEARING AND FUNCTIONAL MOBILITY AMONG OLDER ADULTS AT BASELINE IN THE CANADIAN LONGITUDINAL STUDY ON AGING
(2021-08-31)Mobility problems, prevalent among older adults, are influenced by numerous factors that are interrelated. The primary purpose was to examine the relationship between hearing, measured by Pure-Tone Audiometry, and mobility, ... -
Voluntary Aerobic Exercise Attenuates Frailty in a Sex-Specific Manner in Older Male and Female C67Bl/6 Mice
(2021-08-27)Aerobic exercise is thought to improve overall health and reduce frailty, but whether this is beneficial in both sexes is unclear. We introduced voluntary wheel running to older (~22 months) male and female mice to see if ...