Browsing Faculty of Graduate Studies Online Theses by Subject "Cardiovascular"
Now showing items 1-5 of 5
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The Contribution of Mechanical Effects to Ventricular Arrhythmias during Acute Regional Ischemia
(2015)Arrhythmias during acute regional ischemia can cause sudden cardiac death. Our goal was to investigate the mechanical contribution to ventricular arrhythmias in this setting. Experiments were conducted in Langendorff-perfused ... -
THE IMPACT OF AGE AND FRAILTY ON CARDIAC FUNCTION IN HEALTH AND DISEASE CONDITIONS IN NATURALLY AGEING MICE
(2019-11-28)Frail people with cardiovascular disease experience worse outcomes and higher mortality than non-frail patients, but the links between frailty and myocardial function are unclear. Frailty was quantified as deficit accumulation ... -
Impact of frailty on cardiac contractile function in an aging mouse model
(2014-08-22)This study quantified frailty in a longitudinal study in the mouse model and investigated whether frailty was a better predictor of changes in cardiac morphology and function than chronological age. Frailty scores ... -
Physiological Remodelling of Mitral Valve Chordae Tendineae In The Maternal Bovine Heart
(2016-08-11)Pregnancy is a cardiac volume-overload state that triggers heart valve remodelling. The bovine mitral valve anterior leaflet increases in area by ~35%, with a striking ~22% increase in the number of chordae tendineae ... -
The Role of Altered Calcium-Handling in Mechanically-Induced Arrhythmias During Acute Regional Ischemia
(2016-06-27)Sudden Cardiac Death, a leading cause of death in Canada, commonly occurs as a result of arrhythmias occurring in the first hour of acute regional ischemia (ARI) after coronary artery occlusion. The mechanisms by which ARI ...