Browsing Faculty of Graduate Studies Online Theses by Title
Now showing items 953-972 of 7892
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Characterizing metformin response and sensitivity biomarkers in breast cancer
(2018-09-28)The anti-diabetic drug metformin has been shown to exhibit broad in vitro and in vivo anti-neoplastic activity in various cancer types, including breast cancer. Despite numerous clinical trials ongoing, no targeted biomarkers ... -
Characterizing Mouse V1 Optogenetic-Mediated Rebound Effects
(2023-08-28)Cortical circuits comprise excitatory pyramidal (Pyr) cells and inhibitory interneurons that work together to perform neural computations. Optogenetic studies in mouse primary visual cortex (V1) have focused on (i) sketching ... -
CHARACTERIZING PRESENT AND FUTURE NITRATE LOADING IN A GROUNDWATER-DOMINATED AGRICULTURAL WATERSHED OF A COASTAL LAGOON
(2024-04-05)Basin Head is a coastal lagoon in northeastern PEI, where Nitrate-nitrogen (NO3-N) is conveyed from the agricultural watershed to the eutrophic lagoon via intertidal groundwater springs and groundwater-dominated tributaries. ... -
Characterizing recreational boating patterns based on GPS trajectory points.
(Dalhousie University, 2007) -
Characterizing Renal Tubular Epithelial Injury during Donation after Cardiocircualtory Death (DCD) and Possible Amelioration with PKX-001
(2024-06-26)Deceased donor kidneys from Donation after Circulatory Death (DCD) contribute significantly to transplantation yet pose challenges due to ischemia-reperfusion injury (IRI). This study characterizes renal tubular epithelial ... -
Characterizing Sources of Fecal Pollution at Four Urban Public Beaches in the Halifax Regional Municipality
(2016-03-30)Within the last few years several beaches in the Halifax Regional Municipality have closed frequently due to increased levels of E. coli within the beach waters. Enumeration, microbial enrichment, and genetic microbial ... -
Characterizing The Distinguishability Of Microbial Genomes
(2010-04-29)The field of metagenomics has shown great promise in the ability to recover microbial DNA from communities whose members resist traditional cultivation techniques, although in most instances the recovered material comprises ... -
CHARACTERIZING THE EFFECT OF COLONY STIMULATING FACTORS ON MACROPHAGE METABOLISM AND PHENOTYPE
(2023-08-24)Macrophages are a highly specialized group of immune cells and often referred to as sentinels of the immune system due to their ability to phagocytose cellular debris and pathogens, detect danger signals, and produce ... -
Characterizing the Effects of Experimental Glaucoma and Age on Retinal Ganglion Cell Function
(2023-08-30)Glaucoma is an optic neuropathy characterized by the progressive loss of retinal ganglion cells (RGCs). Clinical monitoring of disease progression uses gross structural changes as surrogate measures of RGC loss. Previous ... -
Characterizing the Effects of IL-5 on Human Mast Cell Gene Expression and Mediator Production
(2023-12-15)Mast cells are tissue resident immune effector cells involved in host defense, inflammation, and immune regulation. Interleukin 5 (IL-5) is a type 2 cytokine elevated in allergic disease and parasitic infections. We ... -
Characterizing the genetic architecture of fitness related traits in an annual grass, Avena barbata.
(Dalhousie University, 2005) -
CHARACTERIZING THE MODULATION OF STRESS GRANULE RESPONSES BY CORONAVIRUSES
(2022-08-31)Coronaviruses (CoVs) are a family of viruses that circulate in human populations causing mild common colds as well as severe and fatal respiratory disease. Stress granules (SGs) are cytoplasmic condensates that often form ... -
Characterizing the Role of Acetylcholinesterase in Mouse Cardiomyoctyte Proliferation and Differentiation
(2013-12-19)There is scarce information on the fate of cardiac progenitor cells (CPC) in the embryonic heart after chamber specification. Furthermore, the role of acetylcholinesterase (AChE) during heart development is unknown, despite ... -
Characterizing The Role Of Atrial Natriuretic Peptide Signalling In The Development Of The Embryonic Ventricular Conduction System
(2018-09-28)Ventricular arrhythmias occur as a result of impairment in the conduction of the electrical impulse in the ventricular conduction system (VCS), and present prominently among the complications encountered by patients with ... -
Characterizing the structure and assembly features of class IB hydrophobins
(2024-08-24)Hydrophobins are small, amphiphilic proteins secreted by filamentous fungi that accumulate at hydrophobic-hydrophilic interfaces and self-assemble into rodlets, resilient repeating β-sheet structures that reverse the ... -
CHARACTERIZING THE TYPE OF INTERLEUKIN-6 SIGNALING IN SEVERE COVID-19
(2023-03-14)Since the beginning of coronavirus disease-19 (COVID-19) pandemic many efforts were made to explore the role of interleukin-6 (IL-6) in COVID-19. I used severe non-COVID-19 to better understand the IL-6 signaling in severe ... -
Charlotte Smith and early British Romanticism: Her writing, her critics, her influence.
(Dalhousie University, 1996) -
Chasing a phantom? A comparative analysis of codes of ethical conduct for legislators.
(Dalhousie University, 2006) -
The Chemerin Receptor GPR1 Signals Through a RhoA/ROCK Pathway and Contributes to Glucose Homeostasis in Obese Mice
(2015-04-02)Chemerin is an adipose-derived hormone that regulates adipose tissue development, immunity, metabolism, and glucose homeostasis. To date, all chemerin function has been attributed to activation of the G protein-coupled ...