Browsing Faculty of Graduate Studies Online Theses by Title
Now showing items 6132-6151 of 7666
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The Role of Guaranteed Income in Healthy Aging: Canadian Public Pensions and their Association with Objective Health Measures
(2022-07-27)Old Age Security (OAS) represents an intervention through which income-related inequalities in health may be improved. The goal of this study was to investigate the allostatic load (AL) of older adults in Canada by level ... -
THE ROLE OF HEME REGULATORY ENZYMES IN MYOCYTES UNDER STRESS
(2016-09-06)The heme metabolism pathway remains a novel therapeutic target for heart failure treatment. However, how heme is regulated in the failing heart remains to be understood. To investigate the molecular mechanisms underlying ... -
The role of hepatic nuclear receptors in systemic lipid homeostasis.
(Dalhousie University, 2007) -
THE ROLE OF IL-17RA- AND IL-17RC-DEPENDENT SIGNALS ON NON-HEMATOPOIETIC CELLS IN SHAPING THE HOST IMMUNE RESPONSES DURING CHLAMYDIA RESPIRATORY TRACT INFECTION
(2018-09-28)The role of IL-17-family cytokines and their receptor-mediated signaling in host defense is complex. During my graduate study, I investigated the specific role of non-hematopoietic IL-17 receptor A (IL-17RA) and IL-17RC ... -
The role of innate-like B1 cells in the regulation of sex-dependent immune responses to Chlamydia infection
(2019-11-28)Chlamydia infections predominantly impact women’s health and the biological basis underlying the sex-dependent disparity is unclear. I demonstrate that female mice are significantly more susceptible to respiratory Chlamydia ... -
Role of Iron Chelation in Inflammation and Infection
(2021-09-14)Iron is an essential element for most forms of life, as its redox-cycling capabilities enable its participation in numerous physiological reactions. However, iron levels must be tightly regulated to avoid free iron toxicity ... -
THE ROLE OF IRON CHELATION IN PULMONARY INFLAMMATION
(2021-08-31)Iron plays a critical role in the human body, e.g., in hemoglobin and DNA synthesis, but it is also important in the regulation of the immune response. Iron’s role in the immune system is closely related to the catalysis ... -
The Role of K+ Channels in Cell Proliferation and Cell Volume Regulation in Human Bronchial Epithelial Cells
(2011-08-19)K+ channels are expressed in a wide variety of cell types, including airway epithelial cells. The purpose of this study was to investigate the role of various Kv and KCa channels in cell proliferation and cell volume ... -
The Role of KSHV microRNAs in Bypass of Oncogene-Induced Senescence
(2016-12-05)Kaposi’s sarcoma-associated herpesvirus (KSHV) is the infectious cause of Kaposi’s sarcoma (KS). KSHV has the ability to bypass a host anti-proliferative defense, oncogene-induced senescence (OIS), triggered by chronic ... -
The role of lateral gene transfer in prokaryotic evolution.
(Dalhousie University, 2003) -
THE ROLE OF LIPID PHOSPHATE PHOSPHATASE 3 IN CARDIAC ENERGY METABOLISM
(2023-07-31)Lysophosphatidic acid (LPA) is a bioactive lipid that is generated by autotaxin (ATX) in circulation and is implicated in obesity induced cardiomyopathy. LPA signaling is terminated by lipid phosphate phosphatase 3 (LPP3) ... -
THE ROLE OF LYSOPHOSPHATIDIC ACID AND AUTOTAXIN IN OBESITY-INDUCED CARDIAC INSULIN RESISTANCE
(2017-08-09)The metabolic changes to adipose tissue during obesity can induce cardiac insulin resistance. During obesity and diabetes, cardiac metabolic flexibility is reduced, which may lead to impaired ATP production, elevated ... -
The role of marine macrophytes in providing essential ecosystem services: Their relative contribution and how services are impacted by eutrophication
(2012-12-14)Most coastal ecosystems are dominated by marine macrophytes that deliver a range of ecologically and economically important services such as carbon and nitrogen cycling and storage, and habitat provision to a range of ... -
The role of mast cells and toll-like receptor 2 (TLR2) in host defence and pathology following Chlamydia infection
(2019-01-15)Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection and the leading cause of infectious blindness worldwide. A comprehensive understanding of immune responses to Ct, and how they lead to ... -
Role of Membrane Curvature and Exosome Secretion during FAST-Mediated Cell-Cell Fusion
(2016-12-05)The fusogenic reoviruses are a unique group of viruses that encode Fusion-Associated Small Transmembrane (FAST) proteins, a family of non-structural membrane proteins that induce cell-cell membrane fusion in infected cells. ... -
THE ROLE OF MICROTUBULES IN ATRIAL MECHANO-ARRHYTHMOGENESIS
(2022-08-08)In the heart, electrical excitation causes mechanical contraction, while feedback of the heart’s mechanical state alters its electrical activity. With mechanical overload, this feedback can result in mechano-arrhythmogenesis ... -
THE ROLE OF MITOCHONDRIAL ANTIOXIDANT ENZYME SUPEROXIDE DISMUTASE 2 (SOD2) IN PLURIPOTENCY AND DIFFERENTIATION
(2020-09-11)The mitochondrial antioxidant enzyme superoxide dismutase 2 (SOD2) is important for maintaining mitochondrial integrity and keeping the levels of reactive oxygen species (ROS) low. Small populations of poorly-differentiated ... -
The role of muscle proteins in the retention of carotenoid in Atlantic salmon flesh.
(Dalhousie University, 2006)