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Thy-1 Signaling in T cells is Weaker and Has Delayed Signaling Kinetics, Promotes Delayed Acquisition and Triggering of Cytotoxic Effector Function, and Preferentially Promotes IL-17A and IL-4 Production in Comparison to TcR Signaling
(2012-09-11)
Thy-1 is a glycosylphosphatidylinositol-anchored protein that is expressed on murine T lymphocytes and is involved in T cell-mediated immune responses. In the presence of costimulatory signals, monoclonal antibody (mAb)-induced ...
INVESTIGATING THE ROLE OF ACTIVATION-INDUCED CYTIDINE DEAMINASE IN CHLAMYDIA PATHOGENESIS
(2023-06-14)
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections around the world. The role of antibodies in Chlamydia pathogenesis remains inconclusive. Activation-induced cytidine deaminase (AID) ...
MITOCHONDRIAL DAMAGE-ASSOCIATED MOLECULAR PATTERNS IMPACT LYMPHOCYTE FUNCTION AND CORRELATE WITH ORGAN HEALTH DURING NORMOTHERMIC MACHINE PERFUSION
(2024-02-06)
Damage-associated molecular pattern (DAMP) molecules from mitochondria (mitoDAMPs) are released following tissue injury. Innate immune cells promote inflammation in response to mitoDAMPs, yet how this is controlled and ...