Browsing Faculty of Graduate Studies Online Theses by Subject "p53"
Now showing items 1-3 of 3
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Dynamic Interplay Between Kaposi's Sarcoma-Associated Herpesvirus Latent Proteins in the Control of Oncogene-Induced Senescence
(2012-04-30)Acute oncogenic stress can activate autophagy and facilitate permanent arrest of the cell cycle through a failsafe mechanism known as oncogene-induced senescence (OIS). Kaposi's sarcoma-associated herpesvirus (KSHV) is the ... -
THE INTERPLAY BETWEEN THE TUMOUR SUPPRESSOR P53 AND ITS NEGATIVE REGULATORS MDM2 AND MDMX
(2020-08-25)p53 is a crucial tumour suppressor that is dysfunctional in most types of cancer. The TP53 gene is frequently mutated in many cancers, resulting in loss of p53 expression or production of mutant p53 proteins that are unable ... -
Molecular Mechanisms of Reovirus Oncolysis
(2013-02-06)Mammalian reovirus is a naturally benign virus that preferentially replicates in cancer cells (reovirus oncolysis) and has been tested as a potential cancer therapy in vitro, in vivo and in clinical trials for treating ...