Browsing Faculty of Graduate Studies Online Theses by Subject "Zebrafish"
Now showing items 1-11 of 11
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Appetitive Learning Paradigm for Zebrafish (Danio rerio) in their Home Tanks Utilising Visual or Olfactory Cues
A visual or olfactory stimulus (green light or phenylethyl alcohol) was presented to groups of adult zebrafish in their home tanks. An automatic feeder dispensed food immediately after the conditioned stimuli (CS), or at ... -
Autonomic innervation and control of chronotropy in the zebrafish heart
In the vertebrate heart the intracardiac nervous system is a common pathway for autonomic control of cardiac output, comprising a population of intracardiac neurons in ganglia embedded within nerve plexi. These neural ... -
Fish Tales: Loss of STAG2 Promotes Migration of Ewing Sarcoma
Ewing sarcoma (EwS) is a bone and soft tissue cancer affecting children and adolescents. The most unfavorable prognostic factor of EwS is the presence of metastasis, however this process is still poorly understood. Therefore, ... -
INVESTIGATING THE TUMOUR SUPPRESSING ROLE OF HACE1 AND ITS NOVEL CONTRIBUTION TO CARDIAC DEVELOPMENT USING THE ZEBRAFISH MODEL
HACE1 is an E3 ubiquitin-ligase that is epigenetically downregulated in various malignancies. The mechanisms underlying its role in tumourigenesis and in normal vertebrate development have not been well elucidated. We ... -
A simple automated system for appetitive conditioning of zebrafish in their home tanks and studying underlying neural activation
Zebrafish are emerging as a novel model for studying learning and memory. However, the number of behavioural paradigms which minimize handling stress and are suited to their social nature is limited. We developed an automated ... -
SYNAPTOPODIN-2, AN ACTIN-BINDING PROTEIN, IS A PROMYOGENIC FACTOR FOR MYOBLAST FUSION AND MYOFIBRILLOGENESIS IN MOUSE AND ZEBRAFISH
Myogenesis is a differentiation-dependent process involving migration and fusion of uninucleated myoblasts to form multinucleated myotubes, the building blocks of striated, contractile muscle fibers. Several actin-binding ... -
USING THE ZEBRAFISH MODEL TO DETERMINE THE ROLE OF THE HACE1 TUMOUR SUPPRESSOR IN NORMAL DEVELOPMENT AND TUMOURIGENESIS
(2011-12-19)HACE1 is a tumour suppressor gene located at human chromosome 6q21. HACE1 is downregulated in Wilms’ tumour as well as several other human cancers. Its role in normal development remains unknown. The zebrafish has established ... -
Using the Zebrafish to Investigate the Role of the NUP98-NSD1 Oncogene and Loss of NUP98 in High-Risk Pediatric Acute Myeloid Leukemia
Many genetic mutations lead to acute myeloid leukemia (AML), including the translocation NUP98-NSD1 (NND1), which is found primarily in pediatric AML and causes high-risk disease. There is currently no animal model of the ... -
Using Zebrafish Xenotransplantation To Study Ewing's Sarcoma And Investigate The Role Of Y-Box Binding Protein 1 In Metastasis
(2015-05-05)The most unfavourable prognostic factor for Ewing’s sarcoma (ES) is the presence of metastases. To date, a viable cancer model for ES metastasis has not been developed. Models for ES are crucial to uncovering the key ... -
Zebrafish Tools To Combat Acute Myeloid Leukaemia – The Nucleoporin 98 kiloDalton—Homeobox A9 (NUP98-HOXA9) Fusion Oncogene Drives Myeloproliferation By Upregulating DNA (Cytosine-5-)-Methyltransferase 1 (dnmt1)
We need to better understand the genetic mechanisms that transform normal blood cells into acute myeloid leukaemia (AML). Overall survival is improving for children and adults with AML, but traditional therapies can be ... -
ZEBRAFISH XENOTRANSPLANTATION AS A PRECLINICAL THERAPEUTIC PLATFORM FOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
Pediatric T-cell Acute Lymphoblastic leukemia (T-ALL) is a high-risk disease. There is a need for targeted therapies for T-ALL, and techniques to rapidly screen drug candidates and personalize patient therapy. I developed ...
