Browsing Faculty of Graduate Studies Online Theses by Subject "Xenotransplantation"
Now showing items 1-3 of 3
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Using Zebrafish Xenotransplantation To Study Ewing's Sarcoma And Investigate The Role Of Y-Box Binding Protein 1 In Metastasis
(2015-05-05)The most unfavourable prognostic factor for Ewing’s sarcoma (ES) is the presence of metastases. To date, a viable cancer model for ES metastasis has not been developed. Models for ES are crucial to uncovering the key ... -
Zebrafish Tools To Combat Acute Myeloid Leukaemia – The Nucleoporin 98 kiloDalton—Homeobox A9 (NUP98-HOXA9) Fusion Oncogene Drives Myeloproliferation By Upregulating DNA (Cytosine-5-)-Methyltransferase 1 (dnmt1)
(2018-02-12)We need to better understand the genetic mechanisms that transform normal blood cells into acute myeloid leukaemia (AML). Overall survival is improving for children and adults with AML, but traditional therapies can be ... -
ZEBRAFISH XENOTRANSPLANTATION AS A PRECLINICAL THERAPEUTIC PLATFORM FOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
(2016-01-14)Pediatric T-cell Acute Lymphoblastic leukemia (T-ALL) is a high-risk disease. There is a need for targeted therapies for T-ALL, and techniques to rapidly screen drug candidates and personalize patient therapy. I developed ...