Browsing Faculty of Graduate Studies Online Theses by Subject "Decitabine"
Now showing items 1-3 of 3
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EVALUATING INHIBITION OF DNA METHYLATION AND ALDH1A3 AS BREAST CANCER THERAPIES
(2020-09-01)Breast cancer is the most common form of cancer among Canadian women. Patients with triple-negative breast cancer (TNBC) have poor prognoses, with inherently more aggressive disease and limited treatment options. New ... -
USING A TRANSGENIC ZEBRAFISH MODEL TO IDENTIFY DOWNSTREAM THERAPEUTIC TARGETS IN HIGH-RISK, NUP98-HOXA9-INDUCED MYELOID DISEASE
(2016-01-14)Acute myeloid leukemia (AML) is a genetic disease whereby sequential genetic aberrations alter essential white blood cell development leading to differentiation arrest and hyperproliferation. Pertinent animal models serve ... -
Zebrafish Tools To Combat Acute Myeloid Leukaemia – The Nucleoporin 98 kiloDalton—Homeobox A9 (NUP98-HOXA9) Fusion Oncogene Drives Myeloproliferation By Upregulating DNA (Cytosine-5-)-Methyltransferase 1 (dnmt1)
(2018-02-12)We need to better understand the genetic mechanisms that transform normal blood cells into acute myeloid leukaemia (AML). Overall survival is improving for children and adults with AML, but traditional therapies can be ...