Browsing Faculty of Graduate Studies Online Theses by Subject "Cardiomyopathy"
Now showing items 1-3 of 3
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NUTRIENT REGULATION OF AUTOPHAGY IN THE HEART
(2016-09-02)Impaired cardiac metabolism in the obese-diabetic heart leads to glucolipotoxicity and ensuing cardiomyopathy. Glucolipotoxicity causes cardiomyocyte injury by increasing energy insufficiency and by dysregulating proteolysis. ... -
THE ROLE OF LIPID PHOSPHATE PHOSPHATASE 3 IN CARDIAC ENERGY METABOLISM
(2023-07-31)Lysophosphatidic acid (LPA) is a bioactive lipid that is generated by autotaxin (ATX) in circulation and is implicated in obesity induced cardiomyopathy. LPA signaling is terminated by lipid phosphate phosphatase 3 (LPP3) ... -
THE ROLE OF LYSOPHOSPHATIDIC ACID AND AUTOTAXIN IN OBESITY-INDUCED CARDIAC INSULIN RESISTANCE
(2017-08-09)The metabolic changes to adipose tissue during obesity can induce cardiac insulin resistance. During obesity and diabetes, cardiac metabolic flexibility is reduced, which may lead to impaired ATP production, elevated ...