Browsing Faculty of Graduate Studies Online Theses by Subject "Cardiac"
Now showing items 1-8 of 8
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Cellular and Subcellular Mechanisms of Ventricular Mechano-Arrhythmogenicity
(2021-07-15)The heart is an electro-mechanical pump with feedback mechanisms for responding to acute changes in its mechanical environment. This requires cellular and subcellular elements of cardiac mechano-sensitivity, including ... -
DELVING INTO THE HEART OF THE MATTER: UNDERSTANDING THE ASSOCIATIONS BETWEEN TGF-β, CTGF AND EARLY MYOCARDIAL CHANGES IN ANGIOTENSIN-II INDUCED MYOCARDIAL FIBROSIS
(2017-03-31)Myocardial fibrosis is the common pathophysiological complication associated with diastolic heart failure. It is characterized by excess extracellular matrix (ECM) protein deposition, which contributes to increased ... -
Effects of Low Testosterone on Frailty and a Selective Androgen Receptor Modulator on Frailty, Frailty Mechanisms, and Cardiac Structure and Function in Older Mice
(2022-09-01)Frailty is a state of increased risk to health issues and can arise in older age and during disease. Low circulating levels of testosterone, especially in older men, are thought to predispose toward a frail state due to ... -
Post-Infarction Rescue of Myocardial Function Using Hemin
(2024-03-20)Acute myocardial infarction is a major contributor to heart failure but has yet to be fully addressed through current therapeutic interventions. In experimental models of myocardial infarction, pre-emptive heme oxygenase-1 ... -
PROCESS TIMES IN PRIMARY PERCUTANEOUS CORONARY INTERVENTION: WHERE DOES THE TIME GO?
(2015)ST-elevation myocardial infarction (STEMI) is a medical emergency and the treatment of choice, if available in a timely manner, is primary percutaneous coronary intervention (PPCI). It is in the best interest of the patient ... -
The Role of Adrenergic Receptor Signaling in Embryonic Ventricular Cell Proliferation and Differentiation
(2019-11-28)In the adult heart, cardiomyocytes (CM) that die in response to aging or pathological insults are replaced by scar tissue. Transplantation of embryonic cardiac progenitor cells (CPC) was shown to increase the contractile ... -
THE ROLE OF MICROTUBULES IN ATRIAL MECHANO-ARRHYTHMOGENESIS
(2022-08-08)In the heart, electrical excitation causes mechanical contraction, while feedback of the heart’s mechanical state alters its electrical activity. With mechanical overload, this feedback can result in mechano-arrhythmogenesis ... -
VALIDATION OF THE PATIENT ACTIVATION MEASURE (PAM-13) AMONG ADULTS WITH CARDIAC CONDITIONS IN SINGAPORE: A MIXED METHODS STUDY
(2016-04-08)The purpose of this study was to validate the Patient Activation Measure (PAM-13) among English-speaking cardiac patients in Singapore. A concurrent mixed methods design was utilized. The quantitative approach was conducted ...