Browsing Faculty of Graduate Studies Online Theses by Subject "Cannabinoids"
Now showing items 1-4 of 4
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CANNABINOID 2 RECEPTOR MODULATION IN EXPERIMENTAL MODELS OF SEPSIS
(2014-08-25)Sepsis is a critical disease where a dysregulated immune response causes multi-organ dysfunction, leading to organ failure and eventual mortality. Early in the course of sepsis, the microcirculation of the intestine is ... -
The Pharmacology of Cannabinoids and Cannabimimetic Ligands in the Eye and their Effects on Intraocular Pressure
(2015)Cannabinoids produce ocular hypotension via activation of cannabinoid receptor type 1 (CB1). Adrenergic receptors (ARs) may contribute to this effect. Recently de-orphaned receptors, GPR55 and GPR18, are activated by some ... -
Phytocannabinoids exert anti-cancer potential in preclinical in vitro models of breast cancer
(2021-08-26)There are a multitude of challenges that are faced in the treatment of breast cancer, such as resistance to chemotherapeutic agents and chemotherapy-induced adverse side effects. Cannabis sativa is used in cancer patients ... -
TARGETING THE ENDOCANNABINOID SYSTEM WITH ORTHOSTERIC AND ALLOSTERIC CANNABINOID LIGANDS TO REDUCE CORNEAL PAIN AND INFLAMMATION
(2019-11-28)The endocannabinoid system, including cannabinoid 1 (CB1R) and cannabinoid 2 (CB2R) receptor, is an emerging target for treating pain and inflammation. This research investigated the effects of orthosteric and allosteric ...