Browsing Faculty of Graduate Studies Online Theses by Subject "Cancer"
Now showing items 21-27 of 27
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A PILOT STUDY OF RESISTANCE EXERCISE FREQUENCY IN BREAST AND OVARIAN CANCER SURVIVORS
(2014-12-16)A large body of research suggests exercise is effective for improving fitness, quality of life (QOL), and fatigue in cancer survivors. Despite evidence in support of exercise, few studies have rigorously evaluated exercise ... -
THE ROLE OF MITOCHONDRIAL ANTIOXIDANT ENZYME SUPEROXIDE DISMUTASE 2 (SOD2) IN PLURIPOTENCY AND DIFFERENTIATION
(2020-09-11)The mitochondrial antioxidant enzyme superoxide dismutase 2 (SOD2) is important for maintaining mitochondrial integrity and keeping the levels of reactive oxygen species (ROS) low. Small populations of poorly-differentiated ... -
The role of the CDP-choline pathway in the anoikis resitance of Ras transformed intestinal epithelial cells
(2012-11-20)Phosphatidylcholine (PC) is an essential component of biological membranes and is synthesized by the CDP-choline pathway under the control of the rate-limiting enzyme CTP:phosphocholine cytidylyltransferase-alpha (CCT?). ... -
THE ROLES OF CHEMOKINES, CHEMOKINE RECEPTORS AND GLYCOLIPID ACTIVATION IN NKT CELL TUMOUR INFILTRATION
(2017-05-11)Higher levels of NKT cell infiltration correlate with improved prognosis in many human cancers. Therefore, we sought to identify factors which contribute to this process. We identified three chemokine receptors, CXCR3, ... -
Synthesis and Biological Evaluation of Prodigiosene Analogues
(2013-10-28)Prodigiosenes are a family of tripyrrolic 4-methoxypyrrolyl-dipyromethane natural products based on the parent compound, prodigiosin. Prodigiosin exhibits significant anti-cancer activity including some ability to specifically ... -
USING THE ZEBRAFISH MODEL TO DETERMINE THE ROLE OF THE HACE1 TUMOUR SUPPRESSOR IN NORMAL DEVELOPMENT AND TUMOURIGENESIS
(2011-12-19)HACE1 is a tumour suppressor gene located at human chromosome 6q21. HACE1 is downregulated in Wilms’ tumour as well as several other human cancers. Its role in normal development remains unknown. The zebrafish has established ... -
Using the Zebrafish to Investigate the Role of the NUP98-NSD1 Oncogene and Loss of NUP98 in High-Risk Pediatric Acute Myeloid Leukemia
(2018-09-28)Many genetic mutations lead to acute myeloid leukemia (AML), including the translocation NUP98-NSD1 (NND1), which is found primarily in pediatric AML and causes high-risk disease. There is currently no animal model of the ...