Browsing by Subject "zebrafish"
Now showing items 1-9 of 9
-
DEVELOPING A TWO-PRONGED DRUG SCREEN TO IDENTIFY COMPOUNDS THAT PROTECT AGAINST CISPLATIN-INDUCED OTO- AND NEPHROTOXICITY
(2021-01-07)Cisplatin is a chemotherapy used to treat a variety of cancers, including several pediatric malignancies. Cancer survivors are plagued by lifelong cisplatin-induced toxicities, including kidney damage and ototoxicity, or ... -
Does Exposure to Simulated Microgravity Affect Cranial Neural Crest-Derived Tissues in Danio rerio?
(2011-09-06)To determine whether exposure to simulated microgravity (SMG) affects cranial neural crest (CNC)-derived tissues, zebrafish embryos were exposed to SMG starting at one of three developmental stages corresponding to CNC ... -
INVESTIGATION OF THE DOPAMINERGIC NEURONS OF THE ZEBRAFISH OLFACTORY BULB THROUGH IMMUNOHISTOCHEMISTRY, BEHAVIOURAL ANALYSIS AND EFFECTS OF ENVIRONMENTAL TOXINS
(2024-08-27)The sense of smell is integral to almost every aspect of life and its loss can be detrimental. Therefore, understanding how the olfactory system functions is essential to investigating potential solutions for its dysfunction. ... -
MECHANICAL CONTROL OF HEART RATE: INVESTIGATING DETERMINANTS OF THE CHRONOTROPIC RESPONSE TO SINOATRIAL NODE STRETCH
(2020-12-08)The sinoatrial node (SAN) is heavily regulated by multiple factors, including stretch, enabling adaptation of heart rate to changes in physiological demand. Right atrial distention, caused by an increase in venous return ... -
Phenotypic plasticity in response to thermal variability within and across generations
(2023-08-25)In their natural habitats, organisms experience environmental variability throughhout their lives at multiple timescales. Yet, their ability to respond to realistic environmental challenges in the long-term is underappreciated ... -
PHLORIDZIN DOCOSAHEXAENOATE INDUCES CYTOTOXIC EFFECTS IN HUMAN LEUKEMIC CELLS
(2017-06-01)Polyphenols have potential as pharmacological adjuvants to overcome some clinical challenges that arise in leukemia management. The efficacy of polyphenols can be enhanced by acylation with fatty acids. In this study, the ... -
SPONTANEOUS ACTIVITY IN THE INTRACARDIAC NERVOUS SYSTEM IN ZEBRAFISH (DANIO RERIO)
(2022-08-12)The final common pathway for neural control of the vertebrate heart consists of autonomic neurons embedded in the cardiac wall, forming the intracardiac nervous system (ICNS). Parasympathetic and sympathetic efferent ... -
Toward Understanding Cranial Sutures in Zebrafish and Chicken
(2016-09-12)Cranial sutures are the fibrous joints between the intramembranous bones of the skull roof that enable the skull to grow in size during the development and growth of the brain. Although the skulls of vertebrate model ... -
UTILIZING ZEBRAFISH TO MODEL THE CHILDHOOD BLINDING DISORDER, FAMILIAL EXUDATIVE VITREORETINOPATHY (FEVR), AND DISCOVER NOVEL THERAPEUTICS
(2017-09-15)Familial exudative vitreoretinopathy (FEVR) is a blinding disorder that results in incomplete peripheral retinal vascularization at birth and there is currently no treatment. Zebrafish were used as a model to mimic a ...