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  • mTORC1 ACTIVATION BY ENDOLYSOSOMAL-DERIVED NUTRIENTS 

    Dixon, Toni-Anne (2024-08-29)
    Cancer cells with oncogenic Ras activate macropinocytosis to acquire nutrients, which are degraded in lysosomes, leading to the activation of mTORC1 and promoting cell growth. Glutamine (Gln) is crucial for mTORC1 activation, ...