Browsing by Subject "Microbiome"
Now showing items 1-14 of 14
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The Association between Birth by Caesarean Section and Otitis Media in Nova Scotian Children
(2017-11-21)Background. Birth by Caesarean section (CS) is a risk factor for allergic disorders, diabetes, and obesity. Otitis media (OM) is a common childhood illness. Risk factors for OM include allergic disorders and obesity; ... -
Cross-Study Analyses of Microbial Abundance Using Generalized Common Factor Methods
(2020-05-15)Micro-organisms seem to flagellate about wherever they please, in our bodies and in the natural and built environments, but they are more cunning than their meandering behavior would suggest. By creating networks of ... -
DRUG USE AND AGE ALTERS THE DRUG METABOLISM POTENTIAL OF THE HUMAN GUT MICROBIOME
(2016-08-23)While drugs play an important role in human health, the interaction between the human microbiome and the metabolism of drugs remains relatively unknown. Studies have demonstrated the microbiome's capability to metabolize ... -
DYNAMICS OF THE GUT VIROME AND BACTERIAL MICROBIOME IN PEDIATRIC CROHN’S DISEASE PATIENTS
(2018-12-17)The human gut microbiome is a dynamic community of bacteria, viruses, and eukaryotic microbes that occupy the gastrointestinal tract. The bacterial microbiome in Crohn’s Disease (CD) patients has been well studied, but ... -
The Effect of Bacterial High Temperature Protein G on Intestinal Epithelial Cells in the Context of Pediatric Crohn’s Disease
(2020-08-07)Crohn’s disease (CD), a type of inflammatory bowel disease, is caused by environmental, microbial, genetic, and immunological factors. Increased expression of specific heat shock proteins (HSPs) in CD patients protects ... -
EVALUATING PREDICTIVE METABOLIC MODELLING TOOLS USING MICROBIOME SEQUENCING-METABOLOMIC DATA
(2021-12-16)Metabolomic technologies have been utilized increasingly in tandem with sequencing technologies in microbiome studies. Combined microbiome-metabolome approaches have fueled the discovery of many convincing associations ... -
Exploring the Potential of the Native Microbial Consortium in Municipal Organics Composts for Biodegradation of Plastic Wastes
(2018-08-27)One of the biggest challenges to the compost industries is plastic contamination. Microorganisms have been reported to have the potential to decompose plastics. A research using next generation amplicon sequencing was ... -
Factors Affecting the Gut Microbiome
(2017-08-30)The recent boom in microbiome research, made possible by advances in sequencing technology, has revealed that the gut microbiome plays an important role in human health. A relatively stable community, gut microbes are ... -
IDENTIFCATION OF ROBUST BIOMARKERS USING MICROBIOME DNA SEQUENCING WITH A FOCUS ON THE ORAL MICROBIOME AND CANCER ASSOCIATIONS
(2022-12-15)High-depth sequencing of universal marker genes such as the 16S rRNA gene is a common strategy to profile microbial communities. Traditionally, sequence reads are clustered into operational taxonomic units (OTUs) at a ... -
Investigating diet as a confounder to asparaginase treatment of acute lymphoblast leukemia
(2023-08-22)Pegaspargase (P-ASP) is an integral part of the treatment of Acute Lymphoblastic Leukemia. P-ASP works by depleting serum asparagine (Asn), killing leukemic but not healthy cells. Whether confounding sources of Asn, for ... -
LONGITUDINAL MULTI-OMIC ANALYSIS OF THE EFFECTS OF INACTIVITY AND EXERCISE ON THE HUMAN MICROBIOME UNDER CONDITIONS OF SIMULATED MICROGRAVITY
(2024-09-26)The Canadian Ageing and Inactivity Study was the first Canadian head-down tilt bedrest study carried out in older adults to evaluate parallels between the effects of microgravity and biological ageing. Host-associated ... -
Probiotic effects on adult anxiety and systemic inflammation after exposure to Western diet
(2019-08-16)Research shows that the microbiome-gut-brain axis affects physiological systems related to food intake, obesity, anxiety, and inflammation. These disorders are related to stress exposure and stress responding is influenced ... -
Probiotics, Pregnancy and The Postpartum Period: Effects of Diet and Probiotic Treatment on Maternal and Offspring Health Outcomes in a Long-Evans Rat Model
(2024-08-28)The Developmental Origins of Health and Disease hypothesis is largely focused on elucidating the mechanisms by which gestational events affect offspring health. This area of research has recently begun examining the interplay ... -
VARIABLE SELECTION BY SUBSAMPLING RANKING FORWARD SELECTION (SURF)
(2023-12-07)Traditional statistical methods face lots of challenges in model fitting, variable selection, and model diagnosis when analysing high-dimensional data. LASSO is one of the most popular regularised approaches for high-dimensional ...