Browsing by Subject "Leukemia"
Now showing items 1-5 of 5
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Enhanced tools to model preleukemia to leukemia transformation
(2020-11-26)Preleukemia to leukemia transformation is one of the least well-understood processes in the hematopoiesis field, which is in no small part due to the lack of models that faithfully recapitulate this phenomenon. In this ... -
Exploring the contributions of 2B4 and CD48 to natural killer cell activation and cancer killing
(2024-07-21)Natural killer (NK) cells are known mediators of immunosurveillance and anti-cancer activity. They prevent cancer growth and relapse and are increasingly used for cancer immunotherapy. NK cells distinguish non-cancerous ... -
Generating Tools to Investigate Infant Leukemia Disease Biology and Identify New Therapies Through Rapid Drug Screening.
(2021-07-23)Infant Leukemia (IL) is a rare and aggressive congenital leukemia that is frequently caused by fusion genes involving lysine methyltransferase MLL (MLL1; KMT2A) and has a dismal prognosis. Further investigation into ... -
Using the Zebrafish to Investigate the Role of the NUP98-NSD1 Oncogene and Loss of NUP98 in High-Risk Pediatric Acute Myeloid Leukemia
(2018-09-28)Many genetic mutations lead to acute myeloid leukemia (AML), including the translocation NUP98-NSD1 (NND1), which is found primarily in pediatric AML and causes high-risk disease. There is currently no animal model of the ... -
ZEBRAFISH XENOTRANSPLANTATION AS A PRECLINICAL THERAPEUTIC PLATFORM FOR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
(2016-01-14)Pediatric T-cell Acute Lymphoblastic leukemia (T-ALL) is a high-risk disease. There is a need for targeted therapies for T-ALL, and techniques to rapidly screen drug candidates and personalize patient therapy. I developed ...