Browsing by Subject "Experimental Autoimmune Encephalomyelitis"
Now showing items 1-3 of 3
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THE EFFECTS OF THE PROTEOGLYCAN ANTAGONIST SURFEN ON ANIMAL MODELS OF DEMYELINATION WITH COMPARISON TO IN VITRO T CELL AND MACROPHAGE RESPONSES
(2018-05-23)Multiple sclerosis (MS) is a debilitating neurodegenerative disorder that currently affects over 3000 Nova Scotians, and is characterized by the autoimmune-mediated destruction of myelin and axons in the central nervous ... -
MODULATION OF IMMUNE FUNCTION AND PROMOTION OF RESTORATIVE GENE EXPRESSION BY AF4 IN A MOUSE MODEL OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2014-02-25)The anti-inflammatory and restorative effects of the flavonoid-enriched fraction AF4 were examined in a mouse model of experimental autoimmune encephalomyelitis (EAE). Relative to EAE mice that received vehicle (water, 10 ... -
NEURONAL MITOCHONDRIAL CALCIUM UNIPORTER DEFICIENCY EXACERBATES AXONAL INJURY AND SUPPRESSES REMYELINATION IN MICE SUBJECTED TO EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2020-08-12)High-capacity mitochondrial calcium (Ca2+) uptake by the mitochondrial Ca2+ uniporter (MCU) is strategically positioned to support the survival and remyelination of axons in multiple sclerosis (MS) by undocking mitochondria, ...