Browsing by Title
Now showing items 19363-19382 of 38316
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INVESTIGATING THE ROLE OF MLLT11 IN SUBVENTRICULAR ZONE NEUROGENESIS AND DEVELOPMENT OF THE OLFACTORY BULB
(2022-08-24)Neurogenesis is the process of generating new neurons in developing and adult brains. This process imparts plasticity to the mammalian brain by allowing novel connections to form and replacing damaged neurons. In later ... -
Investigating the role of MLLT11 in the development of cortical hem derivatives and hippocampal neurogenesis
(2021-03-31)The mammalian Cortical Hem plays a key role in orchestrating the formation of Cajal-Retzius cells, the Choroid Plexus, and hippocampus, a structure crucial to cognition and spatial learning. While several key regulators ... -
Investigating the role of mutanthuntingtin in altered transcription in Huntington's disease.
(Dalhousie University, 2007) -
INVESTIGATING THE ROLE OF NICOTINIC ACID PHOSPHORIBOSYL TRANSFERASE IN CANCER
(2019-11-28)Currently, there is interest in targeting cancer stem cells (CSCs) for cancer therapy. CSCs are characterized by self-renewal and the potential to differentiate into various tumor cell types. One therapeutic strategy is ... -
Investigating the role of the anaerobic protist Blastocystis in the gut microbiome by metagenomic analysis
(2021-05-05)Blastocystis are amongst the most prevalent microbial eukaryotes inhabiting the gastrointestinal tracts of mammals. A bioinformatic workflow was developed to detect Blastocystis in gut metagenomic data and applied to 996 ... -
Investigating the Roles of Mast Cells and Innate Activators in Oral Tolerance
(2013-09-09)Oral tolerance is the state of immunologic non-responsiveness that is established following oral antigen consumption. Failures of oral tolerance can result in food allergy. The mechanisms regulating oral tolerance are ... -
Investigating the Secretion of HtpB, the Multifunctional Chaperonin of Legionella pneumophila
(2016-08-31)Legionella pneumophila is a ubiquitous freshwater pathogen of unicellular eukaryotes, namely several species of amoeba. Following inhalation of Legionella-contaminated aerosols, susceptible human populations may also develop ... -
INVESTIGATING THE STRENGTH AND FAILURE MECHANISM OF HIGHLY INTERLOCKED JOINTED PILLARS USING 2D CONTINUUM MODELS
(2021-03-29)Pillars are commonly used in underground mines to maintain the stability and integrity of the openings. An optimum design of mine pillars dictates that the pillars should be as small as possible and meet the load-bearing ... -
INVESTIGATING THE TUMOUR SUPPRESSING ROLE OF HACE1 AND ITS NOVEL CONTRIBUTION TO CARDIAC DEVELOPMENT USING THE ZEBRAFISH MODEL
(2017-10-12)HACE1 is an E3 ubiquitin-ligase that is epigenetically downregulated in various malignancies. The mechanisms underlying its role in tumourigenesis and in normal vertebrate development have not been well elucidated. We ... -
INVESTIGATING THE UNDERLYING IMMUNLOGICAL MECHANISMS OF PREVIOUSLY INFECTED SARS-CoV-2 INDIVIDUALS IN A UNIVERSITY SETTING: A CROSS-SECTIONAL, SEROPREVALENCE STUDY
(2023-12-13)Since December 2019, the COVID-19 pandemic has resulted in more than 770 million cases of the disease and over 6.9 million deaths worldwide. Although over 70% of the global population has been vaccinated against the ... -
Investigating the Use of Cellular Precision Biopatterning for Generating Functional Skin Equivalents
(2018-04-30)The production of skin equivalents for treating full-thickness wounds has been a long-standing challenge in the field of skin tissue engineering. Although several techniques (e.g., skin substitutes and cell-based therapies) ... -
Investigating Tom1 as a Candidate Regulator of Ptch1
(2012-12-14)Sonic hedgehog (Shh) is a signaling molecule that is involved in patterning the embryo and regulates adult stem cell homeostasis. Patched1 (Ptch1) is the receptor for Shh and upon binding to Shh is endocytosed, allowing ... -
INVESTIGATING TYPE III SECRETION SYSTEM 1 REGULATION IN VIBRIO PARAHAEMOLYTICUS
(2018-09-28)Vibrio parahaemolyticus is a Gram-negative bacterial pathogen found in contaminated shellfish that causes a self-limiting gastroenteritis. It employs multiple virulence factors in its infection of humans, including two ... -
Investigating variations in survival rates for women diagnosed with ovarian cancer in Nova Scotia
(2023-12-14)Introduction: Globally, ovarian cancer is the 6th most common type of cancer among women. Though advancements in early detection and treatment practices continue to improve cancer outcomes, only about half of women who are ... -
Investigating Wildlife Movement Pathways through the Chignecto Isthmus: A Participatory Mapping Approach for Knowledge Co-Production
(2021-08-31)Inclusive knowledge systems that engage local perspectives and social and natural sciences are critical for conservation planning. This thesis explores local tacit knowledge application to identify wildlife locations, ... -
INVESTIGATING WORK-RELATED SERENDIPITY, WHAT INFLUENCES IT, AND HOW IT MAY BE FACILITATED IN DIGITAL ENVIRONMENTS
(2014-01-02)Serendipity is a popular word that captures a rich phenomenon with potentially far-reaching implications from a personal to global level. Serendipity is associated with revelations, discoveries, life events, and innovations, ... -
AN INVESTIGATION OF BOT ACCOUNT IDENTIFICATION ON TWITTER DATA
(2021-04-30)Twitter bots are automated accounts which are programmed to perform certain tasks which resemble those of daily active users such as tweeting, liking a tweet or following. Most of the time, they are designed with malicious ... -
An investigation in marine photochemistry.
(Dalhousie University, 1978) -
An Investigation into Caffeine Intake, Cognition, and Symptomatology in Schizophrenia Patients
(2019-08-29)Patients with schizophrenia consume significantly more caffeine than the general population. Despite this, few studies report on caffeine use, and even fewer on the association between caffeine intake and how it might ... -
An Investigation into Canadian Student Leaders' Conceptualizations and Perceptions Related to Sustainability in Higher Education
(2015-03-31)While universities have a responsibility to engage in sustainability, efforts to do so are not yet standard practice. This may be due to the limited knowledge about how university stakeholders understand sustainability. ...