Browsing by Author "c5f2bd7b-69a7-4374-ab08-8149020f94f9"
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Aberrant Behaviour and Neural Activity in the 5xFAD Mouse Model of Alzheimer's Disease: Exploring Behavioural and Psychological Symptoms of Dementia in a Mouse Model of Amyloid Pathology
Kosel, Filip (2023-08-30)The present work examines behavioural and psychological symptoms of dementia (BPSD)-like behaviours in the 5xFAD mouse model of Alzheimer’s disease (AD)-related amyloid pathology. In particular, this work reviews BPSD-like ... -
Aberrant cortical activity in 5xFAD mice in response to social and non-social olfactory stimuli (Postprint)
Kosel, Filip; Hartley, Mackenzie Rae; Franklin, Tamara Brook (IOS Press, 2024-01-16)Background: Neuroimaging studies investigating the behavioural and psychological symptoms of dementia (BPSD)—such as apathy, anxiety, and depression— have linked some of these symptoms with altered neural activity. However, ... -
CHARACTERIZATION OF SOCIAL DEFICITS IN THE 5XFAD MOUSE MODEL OF ALZHEIMER'S DISEASE
Kosel, Filip (2019-11-28)The 5xFAD mouse strain is a double-transgenic Alzheimer’s disease (AD) model containing mutant APP (K670N/M671L, I716V, and V717I) and PS1 (M146L and L286V) genes. Mice expressing these mutations have rapid accumulation ...