Browsing Pharmacy Faculty Research, Publications and Presentations by Title

Now showing items 4-23 of 24

  • Deprescribing Interventions in Primary Health Care Mapped to the Behaviour Change Wheel: A Scoping Review 

    Isenor JE, Bai I, Cormier R, Helwig M, Reeve E, Whelan AM, Burgess S, Martin-Misener R, Kennie-Kaulbach N. Deprescribing Interventions in Primary Health Care Mapped to the Behaviour Change Wheel: A Scoping Review. Res Social Adm Pharm. 2021 Jul;17(7):1229-1241. https://doi.org/10.1016/j.sapharm.2020.09.005
    Background: Polypharmacy and inappropriate medication use are an increasing concern. Deprescribing may improve medication use through planned and supervised dose reduction or stopping of medications. As most medication ...

  • Development and validation of a sensitive and specific HPLC assay of cladribine for pharmacokinetics studies in rats 

    Yeung, P. K., C. Ferguson, A. Jarrar, B. King, et al. 2007. "Development and validation of a sensitive and specific HPLC assay of cladribine for pharmacokinetics studies in rats." Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 10(2): 231-236.
    PURPOSE: To develop and validate a sensitive and specific HPLC assay for cladribine (CdA) in plasma for pharmacokinetic studies in rats. METHODS: CdA and the internal standard AZT were purchased from Sigma-Aldrich Chem. ...

  • Development and validation of the Chinese version of the Reintegration to Normal Living Index for use with stroke patients 

    Pang, M. Y., R. W. Lau, P. K. Yeung, L. R. Liao, et al. 2011. "Development and validation of the Chinese version of the Reintegration to Normal Living Index for use with stroke patients." Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine 43(3): 243-250.
    OBJECTIVE: To develop and validate a Chinese version of the Reintegration to Normal Living Index. DESIGN: Descriptive case-series. SUBJECTS: Seventy-five individuals with chronic stroke and 55 age-matched healthy subjects. ...

  • Drug Use Management and Policy Residency: A Service-Learning Application 

    Patricia Conrad, Joseph Murphy, and Ingrid Sketris (2005). Drug Use Management and Policy Residency: A Service-Learning Application. American Journal of Pharmaceutical Education: Volume 69, Issue 5, Article 96. doi: 10.5688/aj690596
    Objectives. To establish, implement, and evaluate a drug use management and policy residency program within the context of a service-learning framework. Design. Residents completed a 4-month term in which they were ...

  • Elastase and Tryptase Govern TNF alpha-Mediated Production of Active Chemerin by Adipocytes 

    Parlee, Sebastian D., Jenna O. McNeil, Shanmugam Muruganandan, Christopher J. Sinal, et al. 2012. "Elastase and Tryptase Govern TNF alpha-Mediated Production of Active Chemerin by Adipocytes." Plos One 7(12): 51072-e51072.
    Chemerin is a leukocyte chemoattractant and adipokine with important immune and metabolic roles. Chemerin, secreted in an inactive form prochemerin, undergoes C-terminal proteolytic cleavage to generate active chemerin, a ...

  • Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function 

    Mak, M. C., K. M. Lam, P. K. Chan, Y. B. Lau, et al. 2011. "Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function." PloS one 6(7): 19186. doi:10.1371/journal.pone.0019186
    Nuclear factor of activated T cells 5 protein (NFAT5) is thought to be important for cellular adaptation to osmotic stress by regulating the transcription of genes responsible for the synthesis or transport of organic ...

  • Evaluating the quality of randomized controlled trials that examine the efficacy of natural health products: a systematic review of critical appraisal instruments 

    Whelan, A. M., T. M. Jurgens, and L. Lord. 2009. "Evaluating the quality of randomized controlled trials that examine the efficacy of natural health products: a systematic review of critical appraisal instruments." Evidence-based complementary and alternative medicine : eCAM 6(4): 441-448.
    The purpose of this project was to conduct a systematic review to identify instruments designed to evaluate the quality of randomized controlled trials (RCTs) of natural health products (NHPs). Instruments were examined ...

  • Evaluating the quality of randomized controlled trials that examine the efficacy of natural health products: a systematic review of critical appraisal instruments 

    Whelan, A. M., T. M. Jurgens, and L. Lord. 2009. "Evaluating the quality of randomized controlled trials that examine the efficacy of natural health products: a systematic review of critical appraisal instruments." Evidence-based complementary and alternative medicine : eCAM 6(4): 441-448.
    The purpose of this project was to conduct a systematic review to identify instruments designed to evaluate the quality of randomized controlled trials (RCTs) of natural health products (NHPs). Instruments were examined ...

  • Exercise hemodynamic and neurohormone responses as sensitive biomarkers for diltiazem in rats 

    Yeung, Pollen K. F., Joe D. Feng, and Debbra Fice. 2006. "Exercise hemodynamic and neurohormone responses as sensitive biomarkers for diltiazem in rats." Journal of Pharmacy and Pharmaceutical Sciences 9(2): 245-251.
    Purpose. To investigate the potential of exercise hemodyanamic and neurohormone variables as sensitive biomarkers for pre-clinical evaluation of diltiazem (DTZ). Methods. Sprague Dawley (SD) rats were randomly divided ...

  • Formation of a Collaborative Interprofessional Primary Healthcare Deprescribing Research Team in Nova Scotia 

    Whelan AM, , Kennie-Kaulbach N, Isenor JE Martin-Misener R, Burge F, Burgess S, Kits O, Reeve E, Salsbury LE, Cormier R, Bai I, MacLean H, Helwig M. Formation of a collaborative interprofessional primary health care deprescribing research team in Nova Scotia. 2019 Association of Faculties of Pharmacy of Canada/Canadian Pharmacy Education and Research Conference. Edmonton, AB, June 12 to 13, 2019; Primary Healthcare Research Day in Halifax NS. June17, 2019. (Presenters: AM Whelan, N Kennie-Kaulbach)
    Study objective: To describe the development of a collaborative interprofessional primary health care deprescribing research team in Nova Scotia. Methods: Initiated by two College of Pharmacy faculty members, a core ...

  • Impact of pharmacists as immunizers on vaccination rates: a systematic review and meta-analysis 

    Published version: Isenor JE, Edwards NT, Alia TA, Slayter KL, McNeil SA, MacDougall D, Bowles SK. Impact of pharmacists as immunizers on vaccination rates: a systematic review and meta-analysis. Vaccine. 2016; 34: 5708-23. doi:10.1016/j.vaccine.2016.08.085
    Background: Underutilization of vaccination programs remains a significant public health concern. Pharmacists serve as educators, facilitators, and in some jurisdictions, as administrators of vaccines. Though pharmacists ...

  • Incidence of Deep Vein Thrombosis in Hospitalized Chinese Medical Patients and the Impact of DVT Prophylaxis 

    Cheng, G., C. Chan, Y. T. Liu, Y. F. Choy, et al. 2011. "Incidence of Deep Vein Thrombosis in Hospitalized Chinese Medical Patients and the Impact of DVT Prophylaxis." Thrombosis 2011: 629383. doi:10.1155/2011/629383
    Objective. To evaluate the incidence of deep vein thrombosis in hospitalized Chinese medical patients and the impact of DVT prophylaxis. Methods. All cases of confirmed proximal DVT from 1 January 2005 to 31 December ...

  • Key Priorities to Implement Deprescribing in Primary Health Care in Nova Scotia: Results from the Deprescribing in Primary Health Care in Nova Scotia Knowledge Exchange Event (June 20, 2019) 

    Isenor JE, Kennie-Kaulbach N, Kehoe S, Bai I, Reeve E, Whelan AM, Burgess S, Kits O, Burge F, Martin-Misener R, Helwig M, Sampalli T (OPTx Team). Key Priorities to Implement Deprescribing in Primary Health Care in Nova Scotia: Results from the Deprescribing in Primary Health Care in Nova Scotia Knowledge Exchange Event (June 20, 2019). Final Report. Halifax (NS). 2020 03 03. 46 p.
    Inappropriate medication use and polypharmacy are associated with increased adverse drug reactions, hospitalizations and mortality. Deprescribing has been found to decrease the use of medications and medication costs and ...

  • Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates 

    Huestis, Malcolm P., Gaia A. Aish, Joseph P. M. Hui, Evelyn C. Soo, et al. 2008. "Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates." Organic & Biomolecular Chemistry 6(3): 477-484.
    Structure-based design of alkyl sugar-1-phosphates provides an efficient nucleotidylyltransferase-catalyzed synthesis of a series of new lipophilic sugar nucleotides possessing long or branched alkyl chains, thereby ...

  • Measuring Knowledge Translation Uptake Using Citation Metrics: A Case Study of a Pan-Canadian Network of Pharmacoepidemiology Researchers 

    Melissa Rothfus, Ingrid S. Sketris, Robyn Traynor, Melissa Helwig & Samuel A. Stewart (2016): Measuring Knowledge Translation Uptake Using Citation Metrics: A Case Study of a Pan-Canadian Network of Pharmacoepidemiology Researchers, Science & Technology Libraries, 35(3), 228–240. DOI: 10.1080/0194262X.2016.1192008
    ABSTRACT Collecting citation metric data is important, as research funders are increasingly demanding impact assessment, but there is limited consensus on the most rigorous and accurate approach. We compared three ...

  • A Method for Structure-Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable Streptococci 

    Tian, XiaoLin, Raymond T. Syvitski, TianLei Liu, Nadine Livingstone, et al. 2009. "A Method for Structure-Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable Streptococci." Biological Procedures Online 11(1): 207-226.
    Many species of streptococci secrete and use a competence-stimulating peptide (CSP) to initiate quorum sensing for induction of genetic competence, bacteriocin production, and other activities. These signaling molecules ...

  • The relationship between type of drug therapy and blood glucose self-monitoring test strips claimed by beneficiaries of the Seniors' Pharmacare Program in Nova Scotia, Canada 

    Sanyal, C., S. D. Graham, C. Cooke, I. Sketris, et al. 2008. "The relationship between type of drug therapy and blood glucose self-monitoring test strips claimed by beneficiaries of the Seniors' Pharmacare Program in Nova Scotia, Canada." BMC health services research 8: 111-6963-8-111.
    BACKGROUND: The healthcare expenditure on self-monitoring of blood glucose (SMBG) test strips under the Nova Scotia Seniors' Pharmacare Program (NSSPP) has increased significantly in recent years. The objective of this ...

  • Scale disparity and spectral transfer in anisotropic numerical turbulence 

    Zhou, Y., P. K. Yeung, and J. G. Brasseur. 1996. "Scale disparity and spectral transfer in anisotropic numerical turbulence." Physical review.E, Statistical physics, plasmas, fluids, and related interdisciplinary topics 53(1): 1261-1264. doi:10.1103/PhysRevE.53.1261
    No abstract available.

  • Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans 

    Syvitski, Raymond T., Xiao-Lin Tian, Kamal Sampara, Alan Salman, et al. 2007. "Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans." Journal of Bacteriology 189(4): 1441-1450.
    Streptococcus mutans secretes and utilizes a 21-amino-acid signaling peptide pheromone to initiate quorum sensing for genetic competence, biofilm formation, stress responses, and bacteriocin production. In this study, we ...

  • Synthesis of a novel fluorinated phosphonyl C-glycoside, (3-deoxy-3-fluoro- F β-d-glucopyranosyl)methylphosphonate, a potential inhibitor of β- phosphoglucomutase Postprint 

    Published Version: Madison Carroll-Poehls, David L. Jakeman, Synthesis of a novel fluorinated phosphonyl C-glycoside, (3-deoxy-3-fluoro-β-d-glucopyranosyl)methylphosphonate, a potential inhibitor of β-phosphoglucomutase, Carbohydrate Research, 2023, 108979, ISSN 0008-6215, https://doi.org/10.1016/j.carres.2023.108979
    β-phosphoglucomutase (βPGM) catalyzes the conversion of β-glucose 1-phosphate (βG1P) to glucose-6-phosphate (G6P), a universal source of cellular energy, in a two-step process. Transition state analogue (TSA) complexes ...