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Now showing items 11-17 of 17
NUTRIENT REGULATION OF AUTOPHAGY IN THE HEART
(2016-09-02)
Impaired cardiac metabolism in the obese-diabetic heart leads to glucolipotoxicity and ensuing cardiomyopathy. Glucolipotoxicity causes cardiomyocyte injury by increasing energy insufficiency and by dysregulating proteolysis. ...
Intergenerational Effects of Maternal Health on Pregnancy and Neonatal Outcomes in Nova Scotian Children
(2022-08-31)
Maternal pre-pregnancy body mass index (BMI) is associated with first-generation health outcomes. The literature suggests an increased risk of low birthweight in infants born to mothers who are underweight, while infants ...
Predicting Frontal Lobe H-MRS Metabolite Levels Using Obesity and Metabolic Markers in Individuals with Bipolar Disorder: A Meta-Analysis and Cross-Sectional Study
(2022-07-29)
Obesity and related metabolic disorders, such as metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) impact the brain, particularly in the frontal lobe. Individuals with severe and persistent mental illness (SPMI), ...
The role of secretion associate ras-related GTPase 1b in skeletal muscle insulin signaling
(2023-04-24)
Dysfunctional branched-chain amino acid (BCAA) catabolism increases intracellular branched-chain keto acids (BCKA), which inhibit insulin signaling. The discovery of Secretion Associated Ras-related GTPase-1B (Sar1b), a ...
THE ROLE OF LIPID PHOSPHATE PHOSPHATASE 3 IN CARDIAC ENERGY METABOLISM
(2023-07-31)
Lysophosphatidic acid (LPA) is a bioactive lipid that is generated by autotaxin (ATX) in circulation and is implicated in obesity induced cardiomyopathy. LPA signaling is terminated by lipid phosphate phosphatase 3 (LPP3) ...
Role of Transcription Factor EB in obesity mediated cardiac dysfunction
(2023-08-21)
Lipotoxic complications drive impairment in cardiac function during obesity. Specifically, palmitate toxicity induces ER stress, calcium mishandling and perturbations in lysosomal function by downregulating transcription ...
THE EFFECT OF DIETARY PROTEIN ON SATIETY AND WEIGHT LOSS DURING INTERMITTENT FASTING IN OVERWEIGHT AND OBESE WOMEN
(2023-10-10)
Energy restriction, including IER regimens, is one of the most important obesity treatment and weight-control strategies. These regimens provide health benefits associated with weight reduction. With energy restriction ...