| dc.contributor.author | Yeung, Pollen K. F. | en_US |
| dc.contributor.author | Feng, Joe D. | en_US |
| dc.contributor.author | Fice, Debbra | en_US |
| dc.date.accessioned | 2013-09-24T15:00:37Z | |
| dc.date.available | 2013-09-24T15:00:37Z | |
| dc.date.issued | 2006-05 | en_US |
| dc.identifier.citation | Yeung, Pollen K. F., Joe D. Feng, and Debbra Fice. 2006. "Exercise hemodynamic and neurohormone responses as sensitive biomarkers for diltiazem in
rats." Journal of Pharmacy and Pharmaceutical Sciences 9(2): 245-251. | en_US |
| dc.identifier.issn | 1482-1826 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10222/36715 | |
| dc.description.abstract | Purpose. To investigate the potential of exercise hemodyanamic and neurohormone
variables as sensitive biomarkers for pre-clinical evaluation of diltiazem (DTZ).
Methods. Sprague Dawley (SD) rats were randomly divided into 3 groups (n = 6-8 each),
and each group received DTZ 10 mg/kg twice daily for 5 doses or saline followed by a
treadmill exercise protocol for 7 min with speed set at 7 m/min at 3% grade. The 3rd
group received saline but no exercise. Results. Exercise increased SBP from 108 +/- 2 to
131 +/- 3 mmHg, and HR from 437 +/- 6 to 503 +/- 6 bpm, and plasma epinephrine
concentrations from 2.0 +/- 0.6 to 5.8 +/- 1.7 ng/mL in control rats (p 0.05).
Conclusion. Exercise hemodynamic and neurohormone responses are sensitive biomarkers
which could be used for safety and efficacy evaluation of DTZ and perhaps also other
calcium antagonists in pre-clinical animal models. | en_US |
| dc.relation.ispartof | Journal of Pharmacy and Pharmaceutical Sciences | en_US |
| dc.title | Exercise hemodynamic and neurohormone responses as sensitive biomarkers for diltiazem in
rats | en_US |
| dc.type | article | en_US |
| dc.identifier.volume | 9 | en_US |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.startpage | 245 | en_US |
