Browsing by Subject "Neuroscience"
Now showing items 1-20 of 24
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10 Days of Darkness Does Not Restore Neural or Visual Plasticity in Adult Cats
(2014-12-11)Recently it was demonstrated that 10-days of darkness could restore visual plasticity and promote fast and complete recovery from amblyopia in juvenile kittens (Duffy and Mitchell, 2013). To test whether 10-days of darkness ... -
CANNABINOIDS REGULATE TYPE 1 CANNABINOID RECEPTOR EXPRESSION IN CELL CULTURE MODELS OF HUNTINGTON'S DISEASE
(2012-08-10)Type 1 cannabinoid receptor (CB1) levels decline in the striatum of animal models of Huntington’s disease (HD) and in the brains of human patients suffering from HD prior to other pathogenic changes. CB1 levels can be ... -
Characterization of Cux2 in the Developing Cerebellum
(2015)A goal of developmental neurobiology is to understand the mechanisms involved in generating a mature nervous system. For example, researchers are trying to elucidate the processes of fate restriction, migration and maturation ... -
Contribution of Na(v) channels to the development and function of the retina
(2017-08-31)Voltage gated (Nav) channel isoforms are precisely located in the nervous system and expressed sequentially during development. Because Nav channels control the rising phase of action potentials isoform differences may ... -
Effectiveness of TTX in Promoting Anatomical Recovery from MD in Kittens
(2017-08-01)Monocular deprivation (MD) during the critical period of visual development precipitates neuronal alterations in the dorsal lateral geniculate nucleus (dLGN) of kittens that include significant reduction in axon terminals ... -
Effects of Prenatal Stress and/or Forebrain Atrx Deficiency in C57/B6 Male Mice on Maternal Care and Emotional, Cognitive and Social Development
(2018-12-18)Early life experience influences the developing brain, notably in areas related to stress regulation, cognition and social behaviours. During perinatal development, the brain exhibits high plasticity, and environmental ... -
THE EFFECTS OF STRESS IN EARLY AND LATE ADOLESCENCE ON THE ANXIETY-LIKE, DEPRESSION-LIKE, AND SOCIAL BEHAVIOUR OF MALE AND FEMALE ADULT MICE
(2021-08-05)The effects of adolescent stress on behaviour, and social behaviour in particular, has been scarcely studied despite possible increased neural sensitivity to stress due to the extensive neural development characterizing ... -
ELECTROENCEPHALOGRAPHIC RECORDING DURING NATURALISTIC CONVERSATION: PRELIMINARY INSIGHTS FROM AN EVENT-RELATED POTENTIAL LANGUAGE STUDY
(2021-08-31)EEG hyperscanning, which refers to recording simultaneous EEG data from multiple people, are becoming more popular in language cognition research. Studies have mainly focused on neuro-oscillatory dynamics as it is difficult ... -
Examining the Effects of High Intensity Interval Exercise (HIIE) on Corticospinal Excitability and Motor Learning
(2018-08-02)High-intensity interval exercise (HIIE) is effective in modulating corticospinal excitability (CSE), and it has been shown to facilitate improvements in motor learning. This study examined the effect of HIIE on motor ... -
Interference in sequential grasping: effects of action and perception
(2014-08-22)Past research has shown strong evidence supporting the notion that the visual control of action and the visual perception of objects are mediated by two functionally and anatomically distinct visual systems (Milner & ... -
INVESTIGATING MOTOR INHIBITION IN MOTOR IMAGERY
(2017-09-01)Motor leaning can be achieved via motor execution and motor imagery (MI), where the difference is the lack of overt movement in MI. Many theories exist as to the timing and source of this motor inhibition, however no one ... -
INVESTIGATING THE ROLE OF MLLT11 IN CORTICAL DEVELOPMENT
(2023-08-18)The formation of connections within the mammalian neocortex is highly regulated by both extracellular guidance mechanisms and intrinsic gene expression programs. Dysregulation of these programs has been shown to cause a ... -
Investigating Tom1 as a Candidate Regulator of Ptch1
(2012-12-14)Sonic hedgehog (Shh) is a signaling molecule that is involved in patterning the embryo and regulates adult stem cell homeostasis. Patched1 (Ptch1) is the receptor for Shh and upon binding to Shh is endocytosed, allowing ... -
Investigating Transient Patterns of Human Brain Activity in Normal Ageing
(2024-06-25)The global population is ageing rapidly, and with the increasing population age, comes an increasing need to understand the neurophysiological effects of ageing. Human brain activity consists of a complex combination of ... -
Learning-Model Action Observation: An Investigation in Long-Term Motor Learning Outcomes
(2022-08-26)Early motor learning is driven by error commission and feedback during physical practice (PP). Motor learning can also be facilitated by action observation (AO), which classically involves observing a skilled model flawlessly ... -
Mechanisms Underlying the Learning of Skilled Movement Execution via Motor Imagery
(2021-08-31)Learning to move skillfully is a fundamental behaviour. Motor skills can be learned even in the absence of overt bodily movement through a process known as motor imagery — the mental rehearsal of movement — which has ... -
MICROGLIA RESPONSES IN A RAT MODEL OF CHRONIC SLEEP RESTRICTION
(2020-08-27)Recent research suggests that the brain and body adapt to chronic sleep restriction (CSR) resulting in only modest attempts to recover lost sleep and negatively impacting health over time. Microglia, the immune cells of ... -
MOLECULAR NEUROIMAGING IN ALZHEIMER'S DISEASE: TARGETING BUTYRYLCHOLINESTERASE (BCHE) FOR POSITRON EMISSION TOMOGRAPHY (PET) AND SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) IMAGING OF THE BRAIN
(2019-08-23)Currently, there are no effective means to definitively diagnose Alzheimer’s disease (AD) during life. Molecular imaging of β-amyloid (Aβ) or tau neurofibrillary tangle (NFT) pathology in the AD brain, though informative, ... -
NUCLEAR CALCIUM DYNAMICS IN HIPPOCAMPAL NEURONS
(2016-07-12)Increasing evidence points to neuronal nuclear calcium signalling as a conduit between electrical activity and transcription-dependent changes, and it is possible that different mechanisms of nuclear calcium influx trigger ... -
PHARMACOLOGICAL MANIPULATION OF MICROGLIA TO SUPPRESS NEUROINFLAMMATION AND PROTECT NEURONS
(2023-08-30)Microglia are the resident immune cells of the brain that survey the microenvironment, provide trophic support to neurons, and clear debris to maintain homeostasis and healthy brain function. Microglia are also drivers of ...
