Browsing by Subject "Neurodegeneration"
Now showing items 1-2 of 2
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EXPLORING THE ROLE OF MITOCHONDRIAL CHOLESTEROL IN NIEMANN-PICK TYPE C DISEASE
Niemann-Pick type C (NPC) disease is an autosomal recessive neurodegenerative disorder caused by mutations in Npc1 or Npc2 gene. Npc1 and Npc2 encode a late-endosomal transmembrane and lumenal cholesterol-binding domain ... -
A Novel Model of Elevated Mitochondrial Cholesterol and The Consequences for Mitochondrial Function
Increased mitochondrial cholesterol may induce mitochondrial dysfunction and play a role in the progression of neurodegenerative disease and cancer. The voltage-dependent anion channel of the outer mitochondrial membrane ...
