Browsing by Subject "Mast cells"
Now showing items 1-4 of 4
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DELINEATING THE ROLE OF CALCINEURIN A ALPHA IN THE MAST CELL FCϵRI-MEDIATED IMMUNE RESPONSE
(2020-05-11)Allergies are a health challenge resulting from excessive and inappropriate responses to innocuous antigens (allergens), and a key cellular player is the mast cell. Mast cell activation by allergen initiates a response ... -
EXTRACELLULAR MITOCHONDRIA RELEASED FROM LIVER ISCHEMIA REPERFUSION INJURY ACT AS ALARMINS TO EVOKE INNATE IMMUNE SYSTEM AND TRIGGER INFLAMMATION
(2020-08-07)Ischemia reperfusion injury (IRI) during liver transplantation enhances the immunogenicity of allografts and thus impacts overall graft outcome. This sterile inflammatory insult is known to activate innate immunity and ... -
Investigating mast cell responses and the functional role of Toll-Like Receptor 2 in Chlamydia pathogenesis
(2023-08-31)Chlamydia trachomatis (Ct) is a Gram-negative obligate intracellular bacterium that can cause severe reproductive tract complications in females. In this thesis, I have investigated two aspects of the immune response in ... -
The role of mast cells and toll-like receptor 2 (TLR2) in host defence and pathology following Chlamydia infection
(2019-01-15)Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection and the leading cause of infectious blindness worldwide. A comprehensive understanding of immune responses to Ct, and how they lead to ...
