Browsing by Subject "Immunology"
Now showing items 1-12 of 12
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B cells and antibody in the development of long-term cardiac graft rejection
(2014-03-10)The long-term survival of heart transplants is limited by the development of allograft vasculopathy (AV), a vascular pathology that develops in spite of the use of modern immunosuppressive therapies. Although it is widely ... -
Characterization of memory Natural Killer cell responses and their application in a cell-targeted cancer immunotherapy
(2024-08-14)Numerous research studies have underscored the adaptive immune characteristics exhibited by NK cells in response to various stimuli, ranging from cytokines to viral ligands and haptens. This has fueled considerable interest ... -
CHARACTERIZING THE EFFECT OF COLONY STIMULATING FACTORS ON MACROPHAGE METABOLISM AND PHENOTYPE
(2023-08-24)Macrophages are a highly specialized group of immune cells and often referred to as sentinels of the immune system due to their ability to phagocytose cellular debris and pathogens, detect danger signals, and produce ... -
CONTRIBUTION OF THE VOLTAGE-GATED SODIUM CHANNEL NAV1.6 AND TOLL LIKE RECEPTOR 2 IN THE PATHOPHYSIOLOGY OF EAE
(2021-05-05)Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating, and neurodegenerative disorder of the central nervous system (CNS) with the highest worldwide prevalence existing in Canada and affecting over 3000 Nova ... -
DELINEATING THE ROLE OF CALCINEURIN A ALPHA IN THE MAST CELL FCϵRI-MEDIATED IMMUNE RESPONSE
(2020-05-11)Allergies are a health challenge resulting from excessive and inappropriate responses to innocuous antigens (allergens), and a key cellular player is the mast cell. Mast cell activation by allergen initiates a response ... -
Exploring Crustacean Health: Effect of Profilicollis botulus Infection on the Behaviour of Carcinus maenas and Antilipopolysaccharide Factor Phylogeny in Decapoda
(2022-02-01)Learning more about crustacean health and immunity is important to protect them from infections and disease outbreaks. Little is known about the evolution of antilipopolysaccharide factors (ALFs), so this study examined ... -
Impact of CCR5∆32/∆32 Allogenic Hematopoietic Stem Cell Transplant on Adaptive Immune Parameters in HIV Infection
(2018-07-31)Introduction: Human Immunodeficiency Virus (HIV) is a chronic viral infection without a cure. While antiretroviral medications allow people with the infection live long and healthy lives, treated HIV remains associated ... -
MITOCHONDRIAL DAMAGE-ASSOCIATED MOLECULAR PATTERNS IMPACT LYMPHOCYTE FUNCTION AND CORRELATE WITH ORGAN HEALTH DURING NORMOTHERMIC MACHINE PERFUSION
(2024-02-06)Damage-associated molecular pattern (DAMP) molecules from mitochondria (mitoDAMPs) are released following tissue injury. Innate immune cells promote inflammation in response to mitoDAMPs, yet how this is controlled and ... -
PHARMACOLOGICAL MANIPULATION OF MICROGLIA TO SUPPRESS NEUROINFLAMMATION AND PROTECT NEURONS
(2023-08-30)Microglia are the resident immune cells of the brain that survey the microenvironment, provide trophic support to neurons, and clear debris to maintain homeostasis and healthy brain function. Microglia are also drivers of ... -
THE ROLE OF CASP IN NATURAL KILLER CELL IMMUNE FUNCTION
(2014-03-24)Natural Killer (NK) cells are highly mobile, specialized sub-populations of lymphocytic cells that survey their host to identify and eliminate infected or tumor cells. They are one of the key players in innate immunity and ... -
The role of regulatory T and B cells in host responses to Chlamydia genital tract infection
(2016-01-14)The existence of regulatory T and B cells as important cellular entities in immune responses to infection has been established. The focus of this study was to dissect the role of regulatory T and B cells in regulating the ... -
Role of the CXCR3 Chemokine Receptor Axis in the Combination of Oncolytic Vesicular Stomatitis Virus Therapy and Natural Killer T Cell Immunotherapy in Melanoma
(2023-03-01)Advanced melanoma is highly metastatic and resistant to chemotherapies, with a 5-year survival rate below 30%. This study investigated Natural Killer T (NKT) cell-based immunotherapy in combination with oncolytic vesicular ...
