Browsing by Subject "Biomarkers"
Now showing items 1-6 of 6
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Characterizing metformin response and sensitivity biomarkers in breast cancer
(2018-09-28)The anti-diabetic drug metformin has been shown to exhibit broad in vitro and in vivo anti-neoplastic activity in various cancer types, including breast cancer. Despite numerous clinical trials ongoing, no targeted biomarkers ... -
Defining Biomarkers of Frailty in the Kidney: Implications for Endobiotic and Xenobiotic Metabolism in Mice
(2023-08-08)Frailty describes individuals with increased susceptibility to adverse health outcomes. The frailty index (FI) quantifies frailty by measuring deficit accumulation. This project aimed to characterize the molecular signature ... -
Extracellular vesicle sampling and small RNA analysis from high grade glioma patient plasma for the identification of novel biomarkers and development of organotypic cultures as an ex vivo model for extracellular vesicle production
(2023-08-31)High grade glioma (HGG) tumours secrete extracellular vesicles (EVs) for paracrine signaling into plasma or growth media (in the case of cultured tissues). Isolation of these EVs and their cargo could help to better ... -
Investigating the Association between Arsenic Exposure and Chronic Disease Using Toenail Speciation Biomarkers: A Pilot Study in Atlantic Canada
(2017-09-01)With the support of Atlantic PATH, this study has used the world’s largest collection of toenail samples to investigate the association between chronic disease and arsenic speciation. The results of our study showed no ... -
INVESTIGATING THE UNDERLYING IMMUNLOGICAL MECHANISMS OF PREVIOUSLY INFECTED SARS-CoV-2 INDIVIDUALS IN A UNIVERSITY SETTING: A CROSS-SECTIONAL, SEROPREVALENCE STUDY
(2023-12-13)Since December 2019, the COVID-19 pandemic has resulted in more than 770 million cases of the disease and over 6.9 million deaths worldwide. Although over 70% of the global population has been vaccinated against the ... -
Towards the Development of a Proteomics Workflow for High-throughput Protein Biomarker Discovery
(2010-06-22)Two popular workflows exist for quantitative proteome analysis: two-dimensional polyacrylamide gel electrophoresis (2D-PAGE), with staining to visualize proteins, and multidimensional solution phase separations of isotopically ...