Browsing by Subject "mouse model"
Now showing items 1-3 of 3
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CHARACTERIZATION OF SOCIAL DEFICITS IN THE 5XFAD MOUSE MODEL OF ALZHEIMER'S DISEASE
(2019-11-28)The 5xFAD mouse strain is a double-transgenic Alzheimer’s disease (AD) model containing mutant APP (K670N/M671L, I716V, and V717I) and PS1 (M146L and L286V) genes. Mice expressing these mutations have rapid accumulation ... -
HOST FACTOR REGULATION OF HEPATITIS C VIRUS REPLICATION IN RODENT CELLS
(2010-12-20)Hepatitis C virus (HCV) is a serious global health problem with an estimate of 170 million carriers worldwide. Most individuals exposed to this blood-borne pathogen develop chronic infection, which may result in severe ... -
THE INTERSECTION OF HOST IMMUNITY AND VIRAL EVOLUTION: SPECIFIC AND NON-SPECIFIC HOST IMMUNE PRESSURES HAVE DIFFERENTIAL INFLUENCES ON INFLUENZA VIRUS AND SARS-COV-2 ANTIGENIC CHANGES
(2021-12-22)Improvements to public health strategies surrounding vaccination against mutating respiratory pathogens requires a more in-depth understanding of the host factors driving viral evolution. In this thesis, I used informatic ...