Browsing by Subject "breast cancer"
Now showing items 1-10 of 10
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DEVELOPING NATURAL KILLER T CELL BASED TOOLS AND STRATEGIES FOR TARGETING BREAST CANCER
(2019-04-12)Natural killer T cells are a rare population of immune-regulatory lymphocytes which have been implicated in tumor control. However, the benefit of NKT cell activation therapy in metastatic breast cancer remains poorly ... -
The dietary phytochemical myricetin induces ROS-dependent breast cancer cell death
(2016-01-19)Myricetin is a dietary phytochemical found in a variety of fruits and vegetables. Myricetin has several anti-cancer effects on human cancer cells, including bladder, pancreatic, and colorectal cancers; however, the effect ... -
Identifying Novel Effectors of Breast Cancer Stem Cell Population Equilibrium and Survival
(2020-08-07)Triple negative breast cancer (TNBC) patients face poor survival outcomes possibly due to the presence of a small, yet aggressive population of cells termed cancer stem cells (CSCs). In breast cancer, CSCs are defined ... -
THE IMPACT OF HISTAMINE RECEPTOR 2 ANTAGONISTS ON BREAST CANCER DEVELOPMENT AND MONOCYTIC POPULATIONS
(2018-02-08)Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of cancer-related death. There is an urgent need for immunomodulatory drugs which specifically target immune cells to activate an ... -
NATURAL KILLER T CELL IMMUNOTHERAPY IN COMBINATION WITH RECOMBINANT ONCOLYTIC VESICULAR STOMATITIS VIRUS AND IMMUNE CHECKPOINT THERAPY REDUCES TUMOR BURDEN IN MODELS OF PANCREATIC AND BREAST CANCER
(2022-04-08)Cancer is the leading cause of death in Canada. Current treatments, such as chemotherapy and radiation, have high rates of adverse effects leading to dose-limiting toxicities and reduced therapeutic efficacy. Therefore, ... -
PAN-CANCER GENOMIC PROFILING IDENTIFIES NOVEL BREAST CANCER TARGETS AMONG LONG NON-CODING RNAS
(2023-08-31)Breast cancer is the most prevalent cancer among women, representing a significant health challenge as a quarter of patients eventually succumb to the disease. The identification of novel therapeutic targets is thus critical ... -
PROFILING RETINOID SIGNALING IN TRIPLE-NEGATIVE BREAST CANCER: TOWARDS PRECISION APPLICATIONS
(2019-07-18)Breast cancer is the most common malignancy diagnosed in women, affecting approximately one in eight Canadian women in their lifetime. Clinical decision-making for breast cancer focuses on targeting growth factor signals ... -
"SOME WOMEN ARE JUST SO MUCH BETTER THAN ME:" GOVERNMENTALITY ENACTED THROUGH THE BREAST CANCER SOCIAL MOVEMENT
(2013-03-25)Breast cancer social movements have, in many ways, succeeded in increasing the visibility of the disease in North America, yet researchers understand little about the effects of this visibility; there is little information ... -
Studies on the anticancer properties of pleurocidins: a preclinical evaluation
(2012-11-20)Cationic antimicrobial peptides (CAPs) are small peptides that constitute an important defence against microbial pathogens. Certain CAPs also possess anticancer properties. NRC-03 and NRC-07 are pleurocidins derived from ... -
STUDY OF JADOMYCIN PHARMACOKINETICS AND ANTI-BREAST CANCER ACTIVITY IN BALB/C MICE
(2019-01-15)Breast cancer is the most common form of cancer in Canadian women. Despite numerous therapeutic options, multidrug resistance (MDR) remains an obstacle to successful therapy. Jadomycins are natural products derived ...