Browsing by Subject "autophagy"
Now showing items 1-4 of 4
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Dynamic Interplay Between Kaposi's Sarcoma-Associated Herpesvirus Latent Proteins in the Control of Oncogene-Induced Senescence
(2012-04-30)Acute oncogenic stress can activate autophagy and facilitate permanent arrest of the cell cycle through a failsafe mechanism known as oncogene-induced senescence (OIS). Kaposi's sarcoma-associated herpesvirus (KSHV) is the ... -
KSHV vGPCR: A VIRAL ONCOPROTEIN THAT TRIGGERS AUTOPHAGY AND CELLULAR SENESCENCE
(2013-09-09)Autophagy (literally to ‘self-eat’) is an intracellular, catabolic mechanism to degrade and recycle cytoplasmic contents in response to metabolic, oxidative, and genotoxic stresses. Autophagy plays an important role in ... -
ROLE OF TRANSCRIPTION FACTOR EB (TFEB) IN CARDIAC HEALTH AND DISEASE
(2020-12-18)Cardiomyopathy is prevalent and the leading cause of mortality among obese and diabetic patients. Abnormalities in cardiac energy metabolism trigger myocyte dysfunction that precedes the onset of cardiomyopathy. Lack of ... -
Shigella Effector IpaH9.8 Interacts with Autophagy Transcription Factor ZKSCAN3 and Increases Autophagy During Infection
(2016-01-14)Shigella spp. cause severe diarrheal disease known as shigellosis and are a major problem is countries where clean water and sanitation are lacking. Shigella spp. use a Type 3 Secretion System to deliver effector proteins ...