Browsing by Subject "Tumour suppressor"
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INVESTIGATING THE TUMOUR SUPPRESSING ROLE OF HACE1 AND ITS NOVEL CONTRIBUTION TO CARDIAC DEVELOPMENT USING THE ZEBRAFISH MODEL
(2017-10-12)HACE1 is an E3 ubiquitin-ligase that is epigenetically downregulated in various malignancies. The mechanisms underlying its role in tumourigenesis and in normal vertebrate development have not been well elucidated. We ... -
USING THE ZEBRAFISH MODEL TO DETERMINE THE ROLE OF THE HACE1 TUMOUR SUPPRESSOR IN NORMAL DEVELOPMENT AND TUMOURIGENESIS
(2011-12-19)HACE1 is a tumour suppressor gene located at human chromosome 6q21. HACE1 is downregulated in Wilms’ tumour as well as several other human cancers. Its role in normal development remains unknown. The zebrafish has established ...