Browsing by Subject "Neuroprotection"
Now showing items 1-3 of 3
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Inhibition of the mitochondrial calcium uniporter complex (MCUcx) as a neuroprotective strategy for ischemic stroke
(2023-08-03)Ischemic stroke, typically caused by a clot that blocks a major cerebral artery, is a leading cause of death and disability. Despite intense effort, a viable protective strategy has yet to emerge. Mitochondrial dysfunction, ... -
NEUROPROTECTION AFTER TRAUMATIC SPINAL CORD INJURY THROUGH MITOCHONDRIAL CALCIUM UNIPORTER INHIBITION
(2022-07-28)A common final pathway of secondary spinal cord injury (sSCI) is glutamate excitotoxicity, manifested by calcium (Ca2+) overloading of the neuron. Mitochondria are damaged by excessive intake of cytoplasmic Ca2+ through ... -
Strategies for Neuroprotection and Intraocular Pressure Modulation in Experimental Models of Glaucoma
(2020-01-21)Glaucoma is a blinding eye disease caused by death of retinal ganglion cells (RGCs). Intraocular pressure (IOP) is the only modifiable risk factor, and is the target of all current glaucoma therapeutics. However, IOP ...