Browsing by Subject "Cancer"
Now showing items 1-20 of 36
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Aboriginal Population Data Indicators Pilot
(2012-08-21)The author undertook the “Aboriginal Population Data Indicators pilot Project” as an internship with the Cancer Informatics Unit (CIU) of Juravinski Cancer Centre (JCC) at Hamilton Health Sciences in Hamilton, Ontario, ... -
ALL-TRANS RETINOIC ACID AND ARSENIC TRIOXIDE INDUCE LASTING DIFFERENTIATION AND DEMETHYLATION OF TARGET GENES IN ACUTE PROMYELOCYTIC LEUKEMIA
(2019-11-28)Acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA) experience relapse, while patients treated with ATRA and arsenic trioxide (ATO) are often relapse-free. To understand combination ... -
Characterizing Arsenic Speciation and Metallomic Profiles in Toenail Samples of Atlantic Canadians: A Matched Case-Control Study of Breast, Cervical, Prostate, Urinary, and Skin Cancers
(2020-08-31)Chronic exposure to arsenic and metals has been associated with cancer risk. The research objectives were to 1) characterize the profiles of arsenic speciation and metallomes in the toenails of several cancer groups and ... -
CHARACTERIZING THE EFFECT OF COLONY STIMULATING FACTORS ON MACROPHAGE METABOLISM AND PHENOTYPE
(2023-08-24)Macrophages are a highly specialized group of immune cells and often referred to as sentinels of the immune system due to their ability to phagocytose cellular debris and pathogens, detect danger signals, and produce ... -
CHEMOPREVENTIVE EFFECT OF HASKAP BERRY POLYPHENOLS AGAINST TOBACCO SPECIFIC NITROSAMINE-INDUCED DNA DAMAGE IN NORMAL LUNG EPITHELIAL CELLS IN VITRO
(2017-03-24)The protective effect of polyphenol-rich haskap berry extracts against tobacco-specific nitrosamine ketone (NNK)-induced DNA damage was studied in vitro. Normal lung epithelial BEAS-2B cells were exposed to NNK, and to its ... -
DEVELOPING A TWO-PRONGED DRUG SCREEN TO IDENTIFY COMPOUNDS THAT PROTECT AGAINST CISPLATIN-INDUCED OTO- AND NEPHROTOXICITY
(2021-01-07)Cisplatin is a chemotherapy used to treat a variety of cancers, including several pediatric malignancies. Cancer survivors are plagued by lifelong cisplatin-induced toxicities, including kidney damage and ototoxicity, or ... -
Development of a Policy and Procedure Manual for the Surveillance and Epidemiology Unit, Cancer Care Nova Scotia
(2012-04-30)The internship was completed at the Surveillance and Epidemiology Unit (SEU) at Cancer Care Nova Scotia (CCNS). The SEU is responsible for collecting and analyzing data on all diagnosed cases of cancer in Nova Scotia. This ... -
Development of PDA Version Cancer Management Guidelines
(2012-08-21)The internship was performed in Cancer Care Nova Scotia (CCNS) from May 9th to September 2nd, 2005. The objective of the internship work was to convert the cancer management guidelines developed by Cancer Site Teams of ... -
Doxorubicin Loaded Polyphosphate Glass Microspheres for Transarterial Chemoembolization
(2018-07-19)Polyphosphate glass microspheres (PGM) are currently under development for application in transarterial chemoembolization (TACE), the standard of care treatment for intermediate stage hepatocellular carcinoma. PGMs are ... -
Emerging adult cancer: Parents' psychosocial challenges
(2016-12-14)Previous research on how pediatric cancer affects the parent has found that parents experience decreased sense of personal functioning, mental health, and physical health, and negative changes in close relationships. To ... -
Enhancing Cancer Systemic Therapy Surveillance in Nova Scotia: Development of Quality Indicators and Exploration of a Potential Data Source
(2012-06-05)The internship project described in this report was to research indicators and health care quality frameworks as related to cancer systemic therapy. Part of the project was also to explore the potential linkage of data ... -
ESTABLISHING A PATIENT DERIVED ORGANOTYPIC SLICE CULTURE MODEL OF GLIOBLASTOMA MULTIFORME
(2021-05-06)Glioblastoma Multiforme (GBM) is the most common primary malignant brain tumour and has a median survival of 15 months. Despite many years of research in the field, prognosis remains dismal, due in part to the majority of ... -
EXERCISE TO PREVENT ANTHRACYCLINE-BASED CARDIOTOXICITY IN INDIVIDUALS WITH BREAST OR HEMATOLOGICAL CANCERS
(2018-07-18)Anthracyclines (ACs) are a powerful anti-cancer drug used to treat a wide range of cancers, including those of the breast and blood. It is well established that ACs can lead to cardiac dysfunction and heart failure well ... -
How Cancer Survivors’ Challenges After Treatment Impact Transition to Primary Care-led Follow-up Care
(2023-12-08)Background and Rationale: The transition of cancer survivors from oncology-led care to primary care-led follow-up care is a complex process that can significantly impact their well-being and outcomes. This study aimed to ... -
IDENTIFCATION OF ROBUST BIOMARKERS USING MICROBIOME DNA SEQUENCING WITH A FOCUS ON THE ORAL MICROBIOME AND CANCER ASSOCIATIONS
(2022-12-15)High-depth sequencing of universal marker genes such as the 16S rRNA gene is a common strategy to profile microbial communities. Traditionally, sequence reads are clustered into operational taxonomic units (OTUs) at a ... -
Identifying Environments Associated with Physical Activity and Sedentary Behaviour in Older Colorectal Cancer Survivors
(2014-12-15)Colorectal cancer (CRC) survivors experience a reduction in their quality of life (QOL), even after completing treatment. Physical activity (PA) can improve QOL, but most CRC survivors are not active enough to receive ... -
THE IMPACT OF EXERCISE ON THE RELATIONSHIP BETWEEN SLEEP QUALITY AND CANCER-RELATED FATIGUE IN CANCER SURVIVOR
(2023-08-16)Sleep problems have been linked to a variety of factors in cancer survivors (CS), including the disease itself and the treatment. The inability to sleep is strongly associated with cancer-related fatigue (CRF). CRF is a ... -
Impact of yoga on quality of life for adolescent and young adult non-curative cancer patients: A pilot study
(2014-08-21)Four young adult non-curative cancer patients participated in a 7-week home-based Hatha yoga program, completing measures of quality of life (QOL) and program satisfaction. On average, participants engaged in 71.2 minutes ... -
Investigations in Patient Education Resources & the Generation of Generic Templates for Computerized Patient Education for Cancer Patients
(2012-09-10)The aim of the report was to complete the MHI- internship requirement. This internship was accomplished in NICHE research group under supervision of Dr Raza Abidi. The major purpose of the internship was to apply health ... -
JADOMYCIN B AFFECTS CYCLOOXYGENASE-2 RELATED SIGNALLING AND ACTS SYNERGISTICALLY WITH CELECOXIB TO KILL HUMAN BREAST CANCER CELLS
(2024-04-08)Breast cancer affects 1 in 8 Canadian women and 10-20% of advanced breast cancers are triple negative. Triple negative breast cancers (TNBC) lack receptors required for hormone and targeted therapy and, thus, require ...