Browsing by Subject "Bioinformatics"
Now showing items 1-6 of 6
-
A Cache-Friendly BWT Layout
(2023-08-21)The Burrows-Wheeler Transform (BWT) is a widely used succinct data structure in bioinformatics. However, one of the main concerns that researchers still face when using BWT is its processing time due to the lack of access ... -
DRUG USE AND AGE ALTERS THE DRUG METABOLISM POTENTIAL OF THE HUMAN GUT MICROBIOME
(2016-08-23)While drugs play an important role in human health, the interaction between the human microbiome and the metabolism of drugs remains relatively unknown. Studies have demonstrated the microbiome's capability to metabolize ... -
DYNAMICS OF THE GUT VIROME AND BACTERIAL MICROBIOME IN PEDIATRIC CROHN’S DISEASE PATIENTS
(2018-12-17)The human gut microbiome is a dynamic community of bacteria, viruses, and eukaryotic microbes that occupy the gastrointestinal tract. The bacterial microbiome in Crohn’s Disease (CD) patients has been well studied, but ... -
IDENTIFCATION OF ROBUST BIOMARKERS USING MICROBIOME DNA SEQUENCING WITH A FOCUS ON THE ORAL MICROBIOME AND CANCER ASSOCIATIONS
(2022-12-15)High-depth sequencing of universal marker genes such as the 16S rRNA gene is a common strategy to profile microbial communities. Traditionally, sequence reads are clustered into operational taxonomic units (OTUs) at a ... -
INVESTIGATING A NOVEL CLADE OF ANAEROBIC MICROBIAL EUKARYOTES
(2024-05-23)Metamonads are a diverse group of heterotrophic microbial eukaryotes adapted to living in hypoxic environments. All metamonads but one harbour metabolically altered ‘mitochondrion-related organelles’ (MROs) with reduced ... -
Novel Approaches to Marker Gene Representation Learning Using Trained Tokenizers and Jointly Trained Transformer Models
(2021-08-19)Next-generation DNA sequencing technologies have made marker-gene DNA sequence data widely available. Analysis of microbiome data has many challenges, including sparsity, high cardinality, and intra-study dependencies ...